Senior Scientist, Analytical Development & QC (NucleicAcids)

Socket.dev; Cambridge (MA); On-site; USD 126,000 - 182,000; Full time

Job summary

Serif Biomedicines is seeking a Senior Scientist to lead method development, optimization, and qualification for novel nucleic acid therapeutics and LNP delivery systems. You will mentor junior team members and contribute to fast-paced analytical initiatives within a collaborative ADQC group.

You will drive platform development, troubleshoot analytical assays, and communicate findings clearly to cross-functional teams, enabling robust product characterization and regulatory readiness.

Qualifications

• PhD or equivalent with deep hands-on experience in analytical method development.
• Experience with nucleic acid cargo and LNP products is required.
• Proven ability to independently design and troubleshoot complex experiments.
• Strong communication and mentoring skills.

Responsibilities

• Lead method development and implementation for nucleic acid cargo and LNP product release, stability and characterization.
• Lead experimental studies to optimize analytical method performance (specificity, sensitivity, precision, accuracy, linearity).
• Troubleshoot assay development and instrument issues; act as technical resource for the team.
• Plan studies, schedule development projects and oversee routine testing across programs.
• Provide technical input to regulatory filings and author protocols, data, and reports.

Skills

mRNA/LNP expertise

LC-MS

HPLC

Method development

Mentoring

Data presentation

Education

Ph.D. in Chemistry or related field

M.S. in Chemistry/Biochemistry/Engineering

B.S. in Chemistry or related

Tools

Benchling

MS Office

JMP

GraphPad

Empower

Chromeleon

Job description

Serif Biomedicines is seeking a Senior Scientist to lead method development, optimization, and qualification for novel nucleic acid therapeutics and LNP delivery systems. You will mentor junior team members and contribute to fast-paced analytical initiatives within a collaborative ADQC group.

You will drive platform development, troubleshoot analytical assays, and communicate findings clearly to cross-functional teams, enabling robust product characterization and regulatory readiness.