Analytical Development Scientist, QC & Method Optimization

Socket.dev

Cambridge (MA)

On-site

USD 96,000 - 127,000

Full time

5 days ago

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Benefits offered by this job

Healthcare coverage

Annual incentive program

Retirement benefits

Broad range of benefits

Job summary

Serif Biomedicines in Cambridge, MA seeks an Associate Scientist for the Analytical Development and Quality Control team to build a robust system for testing samples and delivering data on nucleic acid therapeutics and LNP delivery vehicles. This hands-on role also involves mentoring teammates and sustaining scientific rigor in a fast-paced, entrepreneurial setting.

The candidate will contribute to method optimization and qualification, shape analytical capabilities, and work across disciplines

Qualifications

Degree in Chemistry, Biochemical Engineering, Biochemistry, Molecular Biology, Chemical Engineering, Biotechnology or related field.
B.S. degree with 8+ years, M.S. degree with 6+ years of relevant industry experience
Technical expertise in HPLC separations, LC-MS, plate-based assays (e.g. ELISA, qPCR/dPCR, residual protein)
Prior hands-on experience working with mRNA/DNA cargo and LNP products is highly desired
Ability to design, independently execute, and troubleshoot experiments
Strong communication and organization skills; good working knowledge of Benchling, MS Office, JMP, GraphPad, Empower, Chromeleon
Demonstrates attention to detail, meticulous record keeping and personal organization
Ability to analyze, compile, and present experimental data in oral presentations as well as in technical reports
Strong technical writing skills to support method SOPs, protocols, and reports

Responsibilities

Setup, maintain, and optimize a system for efficient sample testing and data delivery
Ensure robustness of generated data through tracking historical data
Execute experimental studies to optimize specificity, sensitivity, precision, accuracy, and/or linearity of analytical methods
Analyze, troubleshoot, and communicate experimental findings clearly and succinctly in oral, written, and visual formats
Troubleshoot assay development and instrument operation issues as they arise
Run assays on samples generated during platform development studies
Maintain inventory of nucleic acid cargo and deliver materials supporting development and formulation activities
Document lab activities in detailed protocols and reports in an electronic lab notebook (Benchling)
Compose and revise SOPs and train team members on new assays
Present experimental results and updates to internal teams
Assist with general laboratory tasks as needed to ensure efficient operations
Work independently and collaboratively in a multidisciplinary team environment.