Senior Scientist, Nucleic Acid Analytics & QC

Flagship Pioneering, Inc.; Cambridge (MA); On-site; USD 126,000 - 182,000; Full time

Job summary

Serif Biomedicines is seeking a highly motivated Senior Scientist to lead method development and qualification for nucleic acid therapeutics and LNP delivery, mentoring junior team members in a fast-paced Analytical Development and Quality Control group in Cambridge, MA.

You will drive platform development, execute benchwork, troubleshoot assays, plan studies, and provide technical input for regulatory filings, collaborating across cross-functional teams.

Qualifications

• Degree in Chemistry, Biochemical Engineering, Biochemistry, Molecular Biology, Chemical Engineering, Biotechnology or related field.
• B.S. degree with 14+ years, M.S. degree with 12+, or Ph.D. with 5+ years of relevant industry experience.
• Hands-on experience with mRNA/DNA cargo and LNP products.
• Technical expertise in HPLC separations or LC-MS with independent method development and troubleshooting.
• Experience mentoring or training junior staff is desirable.
• Strong communication and organizational skills; familiarity with Benchling, MS Office, JMP, GraphPad, Empower, Chromeleon.

Responsibilities

• Lead method development and implementation to support nucleic acid cargo and LNP product release, stability and characterization.
• Lead experimental studies to optimize specificity, sensitivity, precision, accuracy, and/or linearity of analytical methods.
• Troubleshoot assay development and instrument operation issues; act as technical resource for the team.
• Plan experiments, design studies, and schedule development projects and routine testing.
• Support day-to-day analytical work for process development and product characterization.
• Mentor junior colleagues and provide technical guidance.
• Communicate findings clearly in oral, written, and visual formats to internal teams and stakeholders.
• Provide input to regulatory filings and author/manage protocols, data, and reports.

Skills

HPLC/LC-MS experience

Mentoring junior staff

Strong communication

Organizational skills

Education

Bachelor's degree in chemistry or related field

MS/PhD in related field

Tools

Benchling

MS Office

JMP

GraphPad

Empower

Chromeleon

Job description

Serif Biomedicines is seeking a highly motivated Senior Scientist to lead method development and qualification for nucleic acid therapeutics and LNP delivery, mentoring junior team members in a fast-paced Analytical Development and Quality Control group in Cambridge, MA.

You will drive platform development, execute benchwork, troubleshoot assays, plan studies, and provide technical input for regulatory filings, collaborating across cross-functional teams.