Senior Scientist, AAV Downstream (Early Pipeline)

DTX Pharma, a Novartis Company; San Diego (CA); On-site; USD 109,000 - 202,000; Full time

Benefits offered by this job

Comprehensive benefits package

401(k) with company match

Generous time off

Job summary

DTX Pharma, a Novartis Company, seeks a Principal Scientist I/II with extensive AAV gene therapy manufacturing experience to lead downstream purification development for next-generation vectors in San Diego onsite.

The role includes leading a 3-5 person team, coordinating with upstream and analytical groups, and collaborating with disease areas to support early drug discovery and developability assessments. A PhD and 3+ years in biotech process development are preferred.

Qualifications

• PhD in bioprocessing, biochemical engineering, gene therapy or related field with 3+ years of relevant process development experience.
• Experience in people management.
• Knowledge of downstream purification processes including affinity and ion-exchange chromatography.

Responsibilities

• Lead and manage a 3-5 person downstream process team and provide technical support, training, and SME knowledge to assist with the professional development of direct reports.
• Coordinate activities with associates across upstream process and analytical teams.
• Develop strategies in collaboration with Disease Areas and partner with various line functions to support early drug discovery from target selection and validation through lead compound selection and developability assessment.
• Serve as a subject matter expert to transfer manufacturing process knowledge to Technical Research & Development team and advance pipeline programs into clinical phases.
• Lead effort and work collaboratively with Technical Research & Development to develop innovative and cost-effective downstream processes for next-generation AAV.
• Manage multiple project workflow to ensure timely delivery.
• Prepare written reports conforming to defined documentation practices including electronic lab notebook.

Skills

Analytical Thinking

Analytical Thinking

Chemical Biology

Chemistry

Clinical Trials

Collaboration

Communication

Curious Mindset

Data Analysis

Data Management

Design of Experiments (DOE)

Detail-Oriented

Drug Development

Drug Discovery Process

Ethics

Gene Therapy

Immunology

Inventory Management

Laboratory Research

Leading Project Teams

Life Science

Machine Learning (ML)

Management Techniques

Medical Research

Molecular Biology

Education

PhD in bioprocessing, biochemical engineering, gene therapy or related field

Tools

AKTA purification systems

Job description

DTX Pharma, a Novartis Company, seeks a Principal Scientist I/II with extensive AAV gene therapy manufacturing experience to lead downstream purification development for next-generation vectors in San Diego onsite.

The role includes leading a 3-5 person team, coordinating with upstream and analytical groups, and collaborating with disease areas to support early drug discovery and developability assessments. A PhD and 3+ years in biotech process development are preferred.