Gene Therapy Downstream Process Scientist - Onsite Durham

Novartis AG; Durham (CA); On-site; USD 94,000 - 174,000; Full time

Benefits offered by this job

Health, life and disability benefits

401(k) with company match

Paid time off and other benefits

Job summary

Novartis AG in Durham, North Carolina is seeking a Scientist - Downstream Process Development to serve as the downstream functional lead on a gene therapy program. You will design, execute, and interpret studies for AAV and LVV modalities across pre-clinical and clinical assets, and perform hands-on downstream operations at small and large scales.

You will collaborate with cross-functional partners to advance development plans, apply DoE and statistical analyses, prepare technical reports, and

Qualifications

• Bachelor's degree with 4+ years relevant experience or Master’s with 2+ years or PhD with 0–2 years relevant experience.
• Strong background in downstream process development for biologics, viral vectors, or gene therapy.
• Hands-on experience with downstream unit operations such as chromatography, depth filtration, tangential flow filtration, ultracentrifugation, impurity clearance, and adventitious virus clearance.

Responsibilities

• Serve as the downstream functional lead for early- and mid-phase programs on the Drug Substance Sub-Team.
• Independently design, execute, and interpret downstream process development studies for AAV and LVV.
• Perform hands-on downstream operations at small and large scales to deliver high-quality outputs.
• Apply DoE and statistical analyses to interpret results and inform strategy.
• Author technical reports and contribute to regulatory filings, including IND submissions.

Skills

Downstream process development

Statistics

DoE (Design of Experiments)

Cross-functional leadership

Chromatography

AAV/LVV knowledge

Education

Bachelor's degree in biological sciences, pharmaceutical sciences, chemical engineering, or related field

Master's degree

PhD

Job description

Novartis AG in Durham, North Carolina is seeking a Scientist - Downstream Process Development to serve as the downstream functional lead on a gene therapy program. You will design, execute, and interpret studies for AAV and LVV modalities across pre-clinical and clinical assets, and perform hands-on downstream operations at small and large scales.

You will collaborate with cross-functional partners to advance development plans, apply DoE and statistical analyses, prepare technical reports, and