Lead AAV Downstream Scientist, Early Pipeline

Novartis Group Companies; San Diego (CA); In loco; USD 120.000 - 180.000; Tempo pieno

Descrizione del lavoro

Novartis Group of Companies is seeking a Principal Scientist I/II to lead downstream purification efforts for next-generation AAV gene therapy. The role focuses on early-stage process development and developability of lead candidates, with responsibility for transferring process knowledge to TR&D and supporting clinical transitions.

The candidate will manage a small team, collaborate across upstream and analytical groups, and deliver innovative, cost-effective purification strategies with AKTA

Competenze

• PhD in bioprocessing or related field with 3+ years of process development experience in biotech/pharma.
• Experience in people management.
• Knowledge of downstream purification including affinity and ion-exchange chromatography with hands-on AKTA experience.
• Technical proficiency, creativity, and independent thinking.
• Excellent communication to convey complex concepts across teams.
• Strong organization and problem-solving skills in fast-paced environments.
• Ability to work in a matrix setting.

Mansioni

• Lead and manage a 3–5 person downstream process team and provide technical support and SME knowledge.
• Coordinate activities with upstream and analytical teams.
• Develop strategies with Disease Areas and partner with line functions for early drug discovery.
• Transfer manufacturing knowledge to TR&D and advance programs into clinical phases.
• Develop innovative and cost-efficient downstream processes for next-generation AAV.
• Manage multiple project workflows to ensure timely delivery.
• Prepare written reports adhering to documentation practices including ELN.
• Other related duties as assigned.

Conoscenze

People management

Communication

Problem solving

Attention to detail

Formazione

PhD in bioprocessing

Strumenti

AKTA purification systems

Descrizione del lavoro

Novartis Group of Companies is seeking a Principal Scientist I/II to lead downstream purification efforts for next-generation AAV gene therapy. The role focuses on early-stage process development and developability of lead candidates, with responsibility for transferring process knowledge to TR&D and supporting clinical transitions.

The candidate will manage a small team, collaborate across upstream and analytical groups, and deliver innovative, cost-effective purification strategies with AKTA