Lead AAV Downstream Scientist, Early Pipeline

Novartis Group Companies; San Diego (CA); On-site; USD 120,000 - 180,000; Full time

Job summary

Novartis Group of Companies is seeking a Principal Scientist I/II to lead downstream purification efforts for next-generation AAV gene therapy. The role focuses on early-stage process development and developability of lead candidates, with responsibility for transferring process knowledge to TR&D and supporting clinical transitions.

The candidate will manage a small team, collaborate across upstream and analytical groups, and deliver innovative, cost-effective purification strategies with AKTA

Qualifications

• PhD in bioprocessing or related field with 3+ years of process development experience in biotech/pharma.
• Experience in people management.
• Knowledge of downstream purification including affinity and ion-exchange chromatography with hands-on AKTA experience.
• Technical proficiency, creativity, and independent thinking.
• Excellent communication to convey complex concepts across teams.
• Strong organization and problem-solving skills in fast-paced environments.
• Ability to work in a matrix setting.

Responsibilities

• Lead and manage a 3–5 person downstream process team and provide technical support and SME knowledge.
• Coordinate activities with upstream and analytical teams.
• Develop strategies with Disease Areas and partner with line functions for early drug discovery.
• Transfer manufacturing knowledge to TR&D and advance programs into clinical phases.
• Develop innovative and cost-efficient downstream processes for next-generation AAV.
• Manage multiple project workflows to ensure timely delivery.
• Prepare written reports adhering to documentation practices including ELN.
• Other related duties as assigned.

Skills

People management

Communication

Problem solving

Attention to detail

Education

PhD in bioprocessing

Tools

AKTA purification systems

Job description

Novartis Group of Companies is seeking a Principal Scientist I/II to lead downstream purification efforts for next-generation AAV gene therapy. The role focuses on early-stage process development and developability of lead candidates, with responsibility for transferring process knowledge to TR&D and supporting clinical transitions.

The candidate will manage a small team, collaborate across upstream and analytical groups, and deliver innovative, cost-effective purification strategies with AKTA