Lead Downstream Scientist – Gene Therapy Processes

U014 (FCRS = US014) Novartis Pharmaceuticals Corporation; North Carolina; On-site; USD 94,000 - 174,000; Full time

Benefits offered by this job

Health benefits

401(k) with company match

Paid time off

Job summary

Novartis in Durham, North Carolina, is seeking a Scientist - Downstream Process Development to lead downstream activities on a gene therapy program. You will design, execute, and interpret studies for AAV/LVV modalities, and perform hands-on operations at multiple scales while collaborating with cross-functional teams.

The role requires strong DoE, statistical analysis, and communication skills to drive program strategy and deliver robust development outcomes within timelines.

Qualifications

• Hands-on experience in downstream unit operations.
• Experience with chromatography, depth filtration, tangential flow filtration.
• Strong DoE and data-driven decision making.
• Ability to lead technical activities in cross-functional teams.

Responsibilities

• Lead downstream development plans for early- to mid-phase programs.
• Design, execute, and interpret downstream studies for AAV/LVV modalities.
• Perform hands-on downstream operations at both small and large scale.
• Apply data-driven analysis to study results and inform strategy.
• Present study results and recommendations to stakeholders.
• Coordinate lab activities with cross-functional partners.

Skills

Downstream process development

Design of Experiments

DoE

Statistical analysis

Cross-functional collaboration

Leadership

Communication skills

Education

Bachelor’s degree in biological sciences, pharmaceutical sciences, chemical engineering

Master’s degree in relevant field

PhD in relevant field

Job description

Novartis in Durham, North Carolina, is seeking a Scientist - Downstream Process Development to lead downstream activities on a gene therapy program. You will design, execute, and interpret studies for AAV/LVV modalities, and perform hands-on operations at multiple scales while collaborating with cross-functional teams.

The role requires strong DoE, statistical analysis, and communication skills to drive program strategy and deliver robust development outcomes within timelines.