Senior Scientist

BioTalent; Durham (NC); Presencial; USD 110.000 - 170.000; Jornada completa

Descripción de la vacante

BioTalent in Durham, NC seeks a Senior Scientist to advance a targeted cancer therapy pipeline. This hands-on, lab-based role concentrates on elucidating drug efficacy and mechanism of action, with a focus on RTK signaling and HER2 biology.

You will generate data that informs program strategy and supports the development of novel oncology therapeutics. Responsibilities include designing in vitro efficacy and mechanism studies, validating targets, developing CRISPR-engineered cell models, and

Formación

• PhD in Cancer Biology, Molecular Biology, or related field.
• 3+ years of industry and/or postdoctoral oncology research experience.
• Demonstrated expertise in receptor tyrosine kinase biology, preferably HER2 signaling.
• Strong background in oncology pharmacology assays and mechanistic biology studies.
• Experience developing and characterizing cellular models, including CRISPR-engineered systems.
• Track record of scientific communication through publications or presentations.
• Ability to manage multiple projects with minimal supervision.
• Excellent written and verbal communication and strong organizational skills.

Responsabilidades

• Design and execute in vitro efficacy, mechanism of action, target validation, and biomarker studies for oncology programs.
• Apply deep expertise in RTK signaling biology, with HER2-focused experience.
• Manage and maintain cancer and normal cell culture models.
• Generate engineered cell lines using CRISPR and inducible expression systems.
• Develop and optimize reporter-based assays and cellular models.
• Analyze and communicate scientific findings to internal stakeholders and external audiences.
• Contribute to conference abstracts, publications, and other research communications.
• Establish robust experimental workflows, documentation practices, and troubleshooting procedures.
• Support multiple research programs within a fast-paced, collaborative environment.

Conocimientos

Oncology research

RTK biology

CRISPR

Scientific communication

Project management

Cross-functional collaboration

Cell culture

Attention to detail

Communication skills

Educación

PhD in Cancer Biology

Master's degree with significant experience

Herramientas

CRISPR gene editing

Cell culture

Descripción del empleo

We're partnering with an innovative oncology biotech seeking a Senior Scientist to help advance a pipeline of targeted cancer therapies. This is a hands-on, laboratory-based role focused on elucidating drug efficacy and mechanism of action, with a particular emphasis on receptor tyrosine kinase (RTK) biology, ideally HER2.

This position offers the opportunity to play a key role in discovery research, generating critical data that informs program strategy and supports the advancement of novel oncology therapeutics.

The Opportunity

As part of a collaborative research team, you will:

• Design and execute in vitro efficacy, mechanism of action, target validation, and biomarker studies for oncology programs
• Apply deep expertise in RTK signaling biology, with a preference for HER2-focused experience
• Manage and maintain cancer and normal cell culture models
• Generate engineered cell lines using CRISPR and inducible expression systems
• Develop and optimize reporter-based assays and cellular models
• Analyze and communicate scientific findings to internal stakeholders and external audiences
• Contribute to conference abstracts, scientific publications, and other research communications
• Establish robust experimental workflows, documentation practices, and troubleshooting procedures
• Support multiple research programs within a fast-paced, collaborative environment

What We're Looking For

• PhD in Cancer Biology, Molecular Biology, Cell Biology, Biochemistry, Pharmacology, or a related discipline (Master's degree with significant relevant experience will also be considered)
• 3+ years of industry and/or postdoctoral experience in oncology research
• Demonstrated expertise in receptor tyrosine kinase biology, ideally including HER2 signaling and targeted therapies
• Strong background in oncology pharmacology assays and mechanistic biology studies
• Experience developing and characterizing cellular models, including CRISPR-engineered systems
• Track record of scientific communication through publications, presentations, or conference abstracts
• Ability to manage multiple projects simultaneously with minimal supervision
• Strong organizational skills and attention to detail
• Excellent written and verbal communication skills
• Experience working effectively in a cross-functional, matrixed environment

This is an excellent opportunity to join a growing biotechnology company where you'll have the chance to make a meaningful scientific impact while helping to advance next-generation therapies for patients with cancer.

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