Research Scientist

Jazz Pharmaceuticals; Durham (NC); On-site; USD 120,000 - 190,000; Full time

Job summary

Jazz Pharmaceuticals seeks a laboratory-based scientist to design and execute experiments on anticancer compounds with a focus on RTKs, preferably HER2. Responsible for documenting protocols, data, analyses, and conclusions per lab procedures.

This full-time role involves communicating research through publications, conference presentations, abstracts, and patent applications. The candidate will manage cell culture, perform in vitro efficacy and mechanism studies, develop reporter systems, and

Qualifications

• Expertise in receptor tyrosine kinase biology, preferably including HER2.
• Experience with oncology and pharmacology assays.
• Demonstrated ability to publish and present at conferences.

Responsibilities

• Design and execute experiments on RTK/HER2–driven anticancer models.
• Maintain cancer and normal cell line cultures and documentation.
• Create stable cell lines with CRISPR for signaling modulation.
• Develop reporter systems for molecular targets.
• Present results for internal and external communications.
• Assist in preparing conference abstracts and manuscripts.

Skills

RTK biology

HER2 signaling

Oncology experience

Pharmacology assays

Publications experience

Project management

CRISPR editing

Education

Ph.D. in cancer biology or related field

Tools

CRISPR-Cas9

Job description

Brief Description:

Responsible for designing and executing experiments relating to the efficacy and mechanism of action of anticancer compounds with little supervision, with a specific focus on receptor tyrosine kinases (RTKs), preferably HER2. Responsible for documenting and archiving experimental protocols, data, analyses, and conclusions according to established laboratory procedures. Expected to participate in communication of research into publications, conference presentations, abstracts, and patent applications. Self-motivated and works under general supervision on multiple projects. This position is a full time laboratory-based position.

Essential Functions/Responsibilities

• Manage cell culture of cancer and normal cell lines.
• Perform in vitro efficacy, mechanism of action, target validation, and biomarker studies with cancer therapeutics, with an emphasis on RTK/HER2-driven models.
• Create stable cell lines with CRISPR and inducible expression, including lines engineered to modulate RTK/HER2 signaling.
• Create or adapt reporter systems for relevant molecular targets
• Present summary results for internal communications and external presentations.
• Support preparation of conference abstracts and manuscripts for publication as needed.
• Develop proper operational, data documentation, and troubleshooting procedures.
• Such other responsibilities and projects that the Company may assign.

Required Knowledge, Skills, and Abilities

• You must have demonstrated expertise in receptor tyrosine kinase biology, preferably including HER2, with experience characterizing RTK signaling, pathway modulation, and therapeutic mechanisms of action.
• Requires the ability to perform routine laboratory work, sit or stand at a computer for long stretches of time and type. Frequently operates a computer and other office productivity machinery, such as a calculator, copy machine, and computer printer. The person in this position needs to occasionally move about inside the office to access file cabinets and office equipment. May occasionally lift objects up to 25 pounds.
• Three or more years of industry or post-doctoral experience in oncology.
• Experience in oncology and pharmacology assays and techniques.
• Exceptional written and verbal communication including publications and conference presentations.
• Team player who is highly organized and able to manage multiple concurrent projects with minimal oversight.
• Forward-thinking with the ability to anticipate challenges and proactively implement solutions.
• Computer proficient.
• Experience driving advancement of numerous projects simultaneously.
• Ability to identify and initiate tasks, set goals for completion, create timelines, and monitor progress to ensure completion.
• Strong sense of urgency to meet business needs.
• A positive, "hands-on" approach to the position.
• Demonstrated ability to react and respond professionally to changing priorities and timelines.
• Demonstrated success in working in a matrix, cross-functional environment.
• Demonstrated ability to communicate clearly both written and oral and work independently with a high level of attention to detail.

Required/Preferred Education and Licenses

• Ph.D. in cancer biology, molecular/cell biology, biochemistry, pharmacology, or related fields, or master’s degree with relevant experience.

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