Senior Research Associate II/Associate Scientist, Biology

Lycia Therapeutics; South San Francisco (CA); On-site; USD 98,000 - 130,000; Full time

Job summary

A leading biotechnology company in South San Francisco seeks a Senior Research Associate II or Associate Scientist to develop and execute assays supporting innovative therapeutic projects. The role involves collaboration and problem-solving within a dynamic research environment.

Benefits

Annual Bonus

Equity

Generous Benefits Package

Qualifications

• 4-8 years of relevant experience required.
• Previous industry experience is necessary.

Responsibilities

• Generate reproducible bioanalytical and in vitro data.
• Design and execute cell-based assays.
• Collaborate with cross-functional project teams.

Skills

Cell Culture

Immunoassays

Analytical Methods

Problem Solving

Communication

Education

BS or MS in Cell Biology

BS or MS in Molecular Biology

BS or MS in Biochemistry

BS or MS in Immunology

Tools

Flow Cytometry

ELISA

MSD

Luminex

Job description

Lycia Therapeutics, Inc. is a biotechnology company leveraging its lysosomal targeting chimera (LYTAC) platform from Founder and Chemistry Nobel Laureate 2022, Carolyn Bertozzi, to discover and develop first-in-class therapeutics that degrade extracellular and membrane-bound proteins. Lycia’s next generation degraders harness the cell’s endogenous lysosomal trafficking and degradation machinery with the potential to degrade targets previously considered to be intractable, across a spectrum of indications. After raising $105 million in capital in 2021, Lycia is advancing an internal pipeline of novel degraders and has entered a strategic collaboration with Eli Lilly to address key unmet medical needs. In May 2024, Lycia Therapeutics completed a $106.6 million series C financing to advance its pipeline of LYTAC extracellular protein degraders to the clinic. Lycia is headquartered in South San Francisco.

Visit https://lyciatx.com/ for more information.

The Role:

Lycia Therapeutics is seeking a motivated and versatile Senior Research Associate II or Associate Scientist in the Biology group to develop and execute cellular, immunological, and protein binding assays to support pipeline and partnered projects. The individual will work closely both with members of the biology team and across functional groups as part of an innovative research organization to help advance molecules to the clinic.

Key Responsibilities:

• Generate high quality, reproducible bioanalytical and in vitro data with antibodies, antibody conjugates and small molecules to support pipeline project advancement and further development of the LYTAC platform
• Design, optimize and execute cell-based assays and protein-binding assays to evaluate novel therapeutics and understand mechanism of action
• Develop and utilize immunoassays to analyze in vivo samples from PK, PD and efficacy studies
• Evaluate, interpret, and document scientific results and communicate findings
• Collaborate with chemistry and biologics scientists in cross-functional project teams to progress drug discovery and drug development efforts

Requirements:

• BS or MS in cell biology, molecular biology, biochemistry, immunology, or related field with 4-8 years of relevant experience. Previous industry experience is required. Title will be commensurate with years of relevant experience.
• Proficiency in mammalian cell culture and cell-based assays using flow cytometry, luminescence or other related analytical methods
• Expertise conducting immunoassays (e.g. ELISA, MSD or Luminex)
• Experience with biochemical/biophysical methods to measure protein binding or enzymatic activity
• Ability to manage multiple tasks independently and contribute to an integrated team
• Highly motivated team player with excellent written and oral communication skills
• Flexibility to contribute to multiple projects and adapt to changing priorities while remaining well organized
• Creative problem solver with the demonstrated ability to overcome technical challenges

$98,000 - $130,000 a year

The expected base salary range for this SRAII is 98,000-123,000 and Associate Scientist is 105,000-130,000 role. We encourage candidates of all levels to apply as there is often flexibility on job title and responsibilities. Compensation will be based on a variety of factors, including experience, qualifications and internal equity. Lycia offers a competitive employment package that includes an annual bonus, equity, and a generous benefits package.

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status