Senior Research Associate, In Vivo Pharmacology

Arbor Biotechnologies; Cambridge (MA); Vor Ort; USD 85.000 - 95.000; Vollzeit

Benefits dieser Stelle

Bonus

New hire equity

Medical, dental, vision premiums paid

HSA funded deductible

12 weeks parental leave

Parking or transit allowance

401(k) match

Discretionary time off

Zusammenfassung

Arbor Biotechnologies is seeking an in vivo pharmacology specialist in Cambridge to advance gene editing programs through dosing, tissue collection, and molecular readouts. You will work on-site 4–5 days per week under the Senior Scientist, In Vivo Pharmacology.

You will run rodent studies, coordinate studies across labs, and perform molecular assays like qPCR, RNAscope, and ELISA, contributing to IND-enabling work.

Qualifikationen

• Bachelor’s degree with 3+ years industry experience or Master’s with 1+ year.
• Hands-on in vivo rodent studies including dosing, monitoring, blood collection, tissue harvest, necropsy.
• Ability to dose rodents by IV, retro-orbital, or similar routes.
• Process tissues for molecular/biochemical/pharmacodynamic endpoints.
• Experience with qPCR/ddPCR, RT-qPCR, Western blot, ELISA, RNAscope; flow cytometry a plus.

Aufgaben

• Run in vivo pharmacology studies in rodents from dosing to tissue harvest and readouts.
• Coordinate between laboratory and animal facility; schedule studies.
• Process tissues and samples for molecular, biochemical, and pharmacodynamic analyses.
• Run assays such as qPCR/ddPCR, RT-qPCR, Western blot, RNAscope, ELISA.
• Analyze and graph study data; present findings to teams and collaborators.
• Maintain accurate study records and sample inventories.

Kenntnisse

In vivo pharmacology

Rodent handling

Data analysis

Molecular assays

Project coordination

Ausbildung

Bachelor's degree in pharmacology/biology/neuroscience or related field

Master's degree with 1+ year experience

Tools

qPCR/ddPCR

RT-qPCR

Western blot

ELISA

RNAscope

Flow cytometry

Jobbeschreibung

Why this role matters.

Our gene editing programs for neurodegenerative diseases can only advance if in vivo studies show that an editor works in a living animal. This role carries those studies from dosing through tissue collection to the molecular readout. The data you generate feeds the preclinical and IND-enabling work that decides whether a program moves forward.

This role reports to the Senior Scientist, In Vivo Pharmacology. It is on-site in Cambridge, typically 4–5 days per week.

What you’ll own.

• Run in vivo pharmacology studies in rodents, including dosing, monitoring, clinical observations, blood collection, tissue harvest, and necropsy.
• Set up and schedule studies, and coordinate between the laboratory and the animal facility.
• Process tissues and biological samples, and isolate DNA, RNA, and protein for molecular, biochemical, and pharmacodynamic analysis.
• Run assays such as qPCR/ddPCR, RT-qPCR, Western blot, Simple Western/Jess, ELISA, or RNAscope.
• Analyze, interpret, and graph study and assay data in GraphPad Prism and other analysis tools.
• Present findings, study progress, and data summaries to project teams and cross-functional collaborators.
• Keep study records, sample inventories, and protocols accurate and current.

What you’ve done.

• Bachelor’s degree in pharmacology, biology, neuroscience, molecular biology, or a related field with 3+ years of industry experience, or a master’s degree with 1+ year.
• Has run in vivo rodent studies hands‑on, including dosing, monitoring, blood collection, tissue harvest, and necropsy.
• Has dosed rodents by intravenous, retro‑orbital, or comparable routes.
• Has processed animal tissues and biological samples for molecular, biochemical, or pharmacodynamic endpoints.
• Has run molecular and biochemical assays such as qPCR/ddPCR, RT-qPCR, Western blot, Simple Western/Jess, ELISA, or RNAscope; flow cytometry experience preferred.
• Has managed samples and timelines across more than one study at a time.
• Has supported IND‑enabling studies (preferred).

What you’ll get.

The anticipated base salary range for this role is $85,000–$95,000. Actual pay depends on relevant experience, skills, education, internal equity, and other job‑related factors.

Every employee is eligible for a bonus and new hire equity. We pay about 90% of medical, dental, and vision premiums and fund the full deductible on our HSA plan. You’ll also get 12 weeks of parental leave at full pay, paid parking or transit, a 401(k) match, and discretionary time off.

Arbor is an equal opportunity employer. We’re committed to a hiring process and a workplace free of bias and discrimination, and we welcome candidates of every background.