Postdoctoral Fellow — Mass Spec & Protein Degradation

Biopharma Careers; Cambridge (MA); Hybrid; USD 81,000 - 110,000; Full time

Benefits offered by this job

Total Rewards Plan

Flexible work options

Comprehensive benefits

Job summary

Amgen seeks a Postdoctoral Fellow in Massachusetts to generate mechanistic insights that influence analytical control strategies, molecule design, and formulation development across Amgen's pipeline.

The role involves designing and executing MS-based studies of protein fragmentation, applying advanced analytical techniques, and translating findings into practical mitigation strategies. Strong publication record and collaboration within a large scientific team are expected.

Qualifications

• PhD at time of appointment.
• Demonstrated independent design, execution, and interpretation of experiments with a strong publication record (first-author).
• Experience with analytical chemistry and biological protein projects preferred.

Responsibilities

• Generate mechanistic insights that influence analytical control strategy, molecule design, and formulation development.
• Design and conduct MS-based mechanistic studies of protein fragmentation pathways in biologics.
• Apply MS, chromatography, and structural analysis to identify fragmentation products and map fragmentation sites.
• Integrate experimental data with modeling to improve degradation behavior predictions.
• Publish findings in peer-reviewed journals and present at scientific conferences.

Skills

Independent design

First-author publications

Critical thinking

Communication

Education

PhD in Analytical chemistry or related life sciences

Tools

ChemDraw

LC-MS/MS

High-resolution MS

Protein characterization

Job description

Amgen seeks a Postdoctoral Fellow in Massachusetts to generate mechanistic insights that influence analytical control strategies, molecule design, and formulation development across Amgen's pipeline.

The role involves designing and executing MS-based studies of protein fragmentation, applying advanced analytical techniques, and translating findings into practical mitigation strategies. Strong publication record and collaboration within a large scientific team are expected.