Senior Principal Scientist - Translational Muscle Biology Leader

UCB; Cambridge (MA); On-site; USD 180,000 - 260,000; Full time

Job summary

UCB in Cambridge, MA is seeking a Senior Principal Scientist to lead translational biology drug discovery with emphasis on muscle biology. You will shape in vitro and in vivo models and develop cellular and biochemical assays for early programs across multiple neuromuscular targets.

This role combines hands-on bench leadership with team mentorship in a matrix environment, guiding project milestones, adopting new technologies, and collaborating across functions to advance candidate programs.

Qualifications

• PhD with 15+ years or MS with 20+ years in drug discovery, biology, cellular biology, bioengineering or related field.

Responsibilities

• Lead and mentor junior scientists in translational biology.
• Oversee multiple projects ensuring timely milestone delivery.
• Identify and implement new technologies to advance muscle cell biology.
• Design, characterize, and validate primary cell or stem cell/3D models for programs.
• Lead design of cell-based assays to assess therapeutic candidates or targets.
• Maintain a minimum of 30% hands-on bench contribution.
• Drive in vivo and in vitro assays to understand neuromuscular biology.
• Collaborate with cross-functional teams to integrate insights into programs.
• Document, analyze, and present data to internal teams.

Skills

Team leadership

Project management

Innovation

Model development

Assay execution

Lab bench work

Muscle biology

Data management

Cross-functional collaboration

Education

PhD with 15+ years

MS with 20+ years

Job description

UCB in Cambridge, MA is seeking a Senior Principal Scientist to lead translational biology drug discovery with emphasis on muscle biology. You will shape in vitro and in vivo models and develop cellular and biochemical assays for early programs across multiple neuromuscular targets.

This role combines hands-on bench leadership with team mentorship in a matrix environment, guiding project milestones, adopting new technologies, and collaborating across functions to advance candidate programs.