Senior/Principal DMPK Scientist (CNS) – Hybrid

Axonis Therapeutics; Boston (MA); Hybrid; USD 140,000 - 210,000; Full time

Benefits offered by this job

Hybrid work environment

Boston-based biotech environment

Job summary

Axonis Therapeutics in Boston is seeking a Senior/Principal Scientist, DMPK to drive the program-level DMPK strategy and support discovery through early clinical development. This role will collaborate across Chemistry, Biology, and Toxicology, helping advance CNS programs with external partners and internal teams.

The position emphasizes human PK, PK/PD modeling, and data integrity, with a strong drive for strategic ADME/DMPK planning and regulatory documentation.

Qualifications

• PhD in Pharmacokinetics, Pharmaceutics, or related field with a minimum of 3 years of industry experience.
• 3+ years as a small molecule DMPK project representative/lead on cross functional project teams.
• Experience with human PK and dose projections.
• Interest in both discovery and development stage DMPK.
• Some experience with PK/PD modeling and simulation.
• Clear and effective communicator.
• Collaborative mindset, creativity, “can do attitude” and adaptability in a nimble, entrepreneurial biotech environment.
• Legally authorized to work in the US via US citizenship or residency.

Responsibilities

• DMPK representative supporting project decisions from discovery through clinical stages.
• Design and interpret ADME, PK, and PK/PD studies from routine SAR to mechanistic insights working with external partners.
• Drive DMPK design strategy in close collaboration with Medicinal Chemistry.
• Perform human PK and dose projections, supporting the progression of lead compounds through the screening cascade.
• Author DMPK sections of regulatory documents and respond to queries.
• Work collaboratively with the Senior Director of DMPK to design the overall ADME/DMPK strategy for the company.
• Work with in vivo pharmacology to interpret exposure–efficacy data and guide compound progression.
• Contribute to safety and toxicology strategy by ensuring compounds meet advancement criteria.
• Collaborate cross functionally and within matrixed environment to advance projects to required milestones.
• Interface with external ADME/DMPK CRO partners to support compound screening and optimization.
• Contribute to experimental planning, data review, and milestone tracking with vendors.
• Ensure high standards of data integrity, documentation, and reproducibility.
• Present program data and recommendations at internal governance meetings.
• Provide scientific input into portfolio discussions from an ADME/PK perspective.
• Thorough, meticulous, and detail-focused approach to data handling and documentation.
• Contribute to a collaborative, high-rigor company culture.

Skills

Cross-functional collaboration

DMPK project leadership

PK/PD modeling

Data interpretation

Communication skills

Attention to detail

US work authorization

Education

PhD in Pharmacokinetics, Pharmaceutics, or related field

Job description

Axonis Therapeutics in Boston is seeking a Senior/Principal Scientist, DMPK to drive the program-level DMPK strategy and support discovery through early clinical development. This role will collaborate across Chemistry, Biology, and Toxicology, helping advance CNS programs with external partners and internal teams.

The position emphasizes human PK, PK/PD modeling, and data integrity, with a strong drive for strategic ADME/DMPK planning and regulatory documentation.