Senior DMPK & Bioanalytical Sciences Director

Flagship Pioneering; Cambridge (MA); On-site; USD 179,000 - 236,000; Full time

Benefits offered by this job

Healthcare coverage

Annual incentive program

Retirement benefits

Job summary

Alltrna, a clinical‑stage biotech, seeks a Sr. Principal Scientist / Director of DMPK & Bioanalytical Sciences to lead DMPK and bioanalytical strategy across nonclinical and clinical programs in a fast‑paced environment.

This hands‑on role drives PK/PD study design, assay development, and translational biomarker strategy with CRO oversight. The candidate will author regulatory sections, supervise scientists, and collaborate with pharmacology teams to integrate data across portfolios and support

Qualifications

• PhD or equivalent in pharmacokinetics, pharmacology, biochemistry, analytical chemistry, or related field.

Responsibilities

• Lead DMPK and bioanalytical strategy across nonclinical and clinical programs, including PK, biomarker, and translational PD readouts.
• Lead method development, qualification, and validation for bioanalytical assays (GLP/GCP‑compliant as required).
• Design, execute, and oversee PK and PK‑PD studies of tRNAs to evaluate delivery technologies (LNP and others) and biomarker effects.
• Manage and qualify CRO and external lab partners across bioanalytical and PK programs.
• Support nonclinical toxicology programs in collaboration with internal teams and CROs.
• Analyze, interpret, and present DMPK and translational biomarker data to internal leadership and external stakeholders.
• Author nonclinical sections of regulatory filings (e.g., IND) and briefing documents; support agency interactions and responses.
• Serve on the Research Leadership Team; represent DMPK and bioanalytical sciences in cross‑functional program discussions.
• Manage and develop direct report(s); collaborate with the broader pharmacology team.

Skills

DMPK

Bioanalytical

PK/PD studies

Method development

GLP/GCP

Regulatory writing

People leadership

Education

PhD or equivalent in pharmacokinetics, pharmacology, biochemistry, analytical chemistry, or related field

Tools

Mass spectrometry

ELISA

NGS

MSD

Luminex

Job description

Alltrna, a clinical‑stage biotech, seeks a Sr. Principal Scientist / Director of DMPK & Bioanalytical Sciences to lead DMPK and bioanalytical strategy across nonclinical and clinical programs in a fast‑paced environment.

This hands‑on role drives PK/PD study design, assay development, and translational biomarker strategy with CRO oversight. The candidate will author regulatory sections, supervise scientists, and collaborate with pharmacology teams to integrate data across portfolios and support