Senior Molecular Biodistribution Scientist

askbio

Durham (NC)

On-site

USD 85,000 - 125,000

Full time

3 days ago

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Job summary

AskBio Inc., a Bayer subsidiary, seeks a Senior Research Associate, Molecular Biodistribution, to execute biodistribution and gene expression experiments at the RTP, NC site. You will perform fit-for-purpose molecular assays, generate tissue distribution and transgene data, and help inform candidate selection, dose strategy, and safety assessments.

The role collaborates with Product Development, Translation Medicine, Tech Ops, and R&D, combining hands-on assay development with data analysis and

Qualifications

Bachelor's or Master's in molecular biology or related with related work experience (5+ yrs for Bachelor's, 2+ yrs for Master's).
Experience in biotech/pharma CRO or academic translational research supporting genetic medicine or related modalities.
Direct experience executing biodistribution and gene expression studies for gene therapy, especially AAV-based programs.
Hands-on experience with nucleic acid extraction from tissues and biofluids and with qPCR/ddPCR/RT-qPCR.
Experience supporting preclinical drug development, including non-GLP and/or GLP studies, and regulated documentation.
Understanding nonclinical development considerations for genetic medicines, including tissue tropism and vector persistence.

Responsibilities

Develop, optimize, and troubleshoot molecular assays to quantify vector genomes, transgene expression, and related biomarkers in tissues and biofluids.
Apply and oversee qPCR-based and related molecular methods (ddPCR, RT-qPCR) with proper controls and data quality practices.
Collaborate with internal stakeholders and external partners for assay transfer and sample analysis.
Drive continuous improvement in assay sensitivity, specificity, reproducibility, and scalability.
Analyze biodistribution and gene expression data to inform program decisions and regulatory submissions.