Pharmacometric Scientist: PK/PD Modeling & Simulation

Amgen SA; Thousand Oaks (CA); On-site; USD 150,000 - 190,000; Full time

Benefits offered by this job

Retirement and savings plan

Comprehensive medical/dental/vision

Job summary

Amgen is seeking a Principal Scientist in Modeling & Simulation to support clinical pharmacology programs across multiple therapeutic areas. In this role, you will build pharmacostatistical models to inform dose selection and analysis strategies, contributing to reporting for regulatory submissions.

You will work within the Clinical Pharmacology, Modeling and Simulation department, collaborating cross‑functionally to advance translational science and optimize trial designs.

Qualifications

• Doctorate degree PhD OR professional equivalent (PharmD/MD) with 2 years PK/PD or statistical modeling experience.
• Master’s degree with 5 years of PK/PD or statistical modeling experience.
• Bachelor’s degree with 7 years of PK/PD or statistical modeling experience.
• Preferred: PhD in related fields with 3 years PK/PD or statistical modeling experience.

Responsibilities

• Build pharmacostatistical models to support Population PK/PD and exposure‑response analyses.
• Conduct binary, categorical, time‑to‑event, Poisson, and Bayesian analyses as applied to PK/PD.
• Perform meta-analysis using proprietary and/or literature data.
• Participate in cross‑functional teams and provide input for dose selection and study design.
• Contribute to clinical pharmacology strategy and project plans.
• Generate modeling reports for regulatory submissions.

Skills

Pharmacometric modeling

Statistical modeling

PK/PD analysis

Cross-functional collaboration

Education

PhD in pharmaceutical sciences / biostatistics / related field

PharmD

MD with PK/PD experience

Master’s degree in related field

Bachelor’s degree in related field

Tools

NONMEM

SAS

R

STAN

MATLAB

Job description

Amgen is seeking a Principal Scientist in Modeling & Simulation to support clinical pharmacology programs across multiple therapeutic areas. In this role, you will build pharmacostatistical models to inform dose selection and analysis strategies, contributing to reporting for regulatory submissions.

You will work within the Clinical Pharmacology, Modeling and Simulation department, collaborating cross‑functionally to advance translational science and optimize trial designs.