Senior Medical Director, Clinical Development Leader

Climb Bio; Wellesley (MA); Hybrid; USD 305,000 - 410,000; Full time

Benefits offered by this job

Discretionary bonus

Medical, Dental and Vision

Life & Disability

401k match

Generous PTO

Equity

Job summary

Climb Bio in Wellesley, MA is seeking a Sr. Medical Director, Clinical Development to lead medical strategy for budoprutug through Phase 2/3 and pivotal studies.

You will shape the evidentiary package, interact with health authorities, and oversee CROs and study teams to deliver registrations. The role requires MD or MD/PhD with 10+ years of biotech/pharma experience, strong leadership, and experience in autoimmune or B-cell-mediated diseases, with a track record of cross-functional

Qualifications

• MD or MD/PhD required with clinical training in a relevant specialty.
• Minimum 10+ years in biotech/pharma clinical development with program-level responsibility.
• Experience as clinical lead on Phase 2 and 3 studies, including design and monitoring.
• Experience guiding programs to registration (BLA/NDA/MAA).
• Therapeutic area experience in autoimmune or immune-mediated disease.

Responsibilities

• Serve as clinical lead for budoprutug with medical and scientific leadership through registration.
• Drive clinical development strategy, study design, endpoints, and evidence package.
• Author and own core study documents and briefing materials.
• Medical monitor for studies: safety, efficacy, and data quality oversight.
• Lead cross-functional workstreams with operations, biostatistics, and regulatory.
• Engage in health authority interactions and prep for meetings.
• Oversee CROs, labs, and external committees; interface with investigators and boards.
• Contribute to publications, congress presentations and scientific communications.

Skills

Clinical leadership

Regulatory knowledge

Cross-functional collaboration

Education

MD or MD/PhD

Job description

Climb Bio in Wellesley, MA is seeking a Sr. Medical Director, Clinical Development to lead medical strategy for budoprutug through Phase 2/3 and pivotal studies.

You will shape the evidentiary package, interact with health authorities, and oversee CROs and study teams to deliver registrations. The role requires MD or MD/PhD with 10+ years of biotech/pharma experience, strong leadership, and experience in autoimmune or B-cell-mediated diseases, with a track record of cross-functional