Senior Mechanical Design Engineer

Zeta Holding GmbH; King of Prussia (PA); Hybrid; USD 110,000 - 170,000; Full time

Benefits offered by this job

Free Coffee

Competitive PTO & Vacation

Hybrid Work Schedule

401K with 5% employer match

Job summary

ZETA in King of Prussia, PA is seeking a Senior Mechanical Design Engineer to lead the design and development of advanced process systems for biopharma projects, including upstream/downstream and cell therapies. You will mentor junior engineers, ensure GMP and ASME BPE compliance, and collaborate across fabrication, automation, and process teams to deliver robust mechanical solutions on complex projects.

Hybrid work with three onsite days per week; travel up to 15% may be required to support

Qualifications

• Bachelor’s degree in Mechanical Engineering or related field.
• 7+ years of mechanical design experience, preferably in biopharma or process industries.
• Proficiency in 2D and 3D CAD modeling, design standards, and engineering best practices.

Responsibilities

• Lead Mechanical Engineering scope throughout the full project lifecycle.
• Lead development of complex 3D models, assemblies, and mechanical system designs.
• Develop P&IDs, 2D layouts, specifications, detailed drawings, and engineering documentation.
• Ensure designs comply with GMP, ASME BPE, and relevant engineering standards.
• Oversee and mentor junior engineers, providing technical guidance.
• Translate process engineering requirements into robust mechanical solutions.
• Lead mechanical design reviews, DFMEAs, tolerance analyses, and risk assessments.
• Collaborate with fabrication, automation, and process engineering teams.
• Support clients, vendors, and manufacturing teams throughout the project lifecycle.

Skills

Mechanical design

3D CAD

GMP compliance

ASME BPE

Education

Bachelor’s degree in Mechanical Engineering

Tools

CAD software

Job description

ZETA is a globally active solutions provider that supports pharmaceutical and biotech companies in bringing vital medicines – such as insulin, infusions, and cancer treatments – to market faster and more efficiently.As an innovation leader, we combine technical expertise with digital excellence, covering everything from planning and construction to automation and qualification of customized process systems. In addition, we take on full responsibility for complex projects as an EPCMV partner, drive digital transformation, and develop sustainable strategies for decarbonization.

Location: King of Prussia Contract: Full-time employee Start: 30.11.2026

The Senior Mechanical Design Engineer leads mechanical design and engineering activities for ZETA’s biopharmaceutical client projects. This role drives the design and development of advanced process systems for upstream processing, downstream purification, plasma fractionation, ADC manufacturing, and cell and gene therapy applications.
The Senior Mechanical Design Engineer serves as a technical leader, guiding junior engineers, leading design reviews, ensuring GMP and ASME BPE compliance, and acting as a key contributor in cross‑functional engineering teams.

Key Responsibilities

• Lead Mechanical Engineering scope throughout the full project lifecycle.


• Lead development of complex 3D models, assemblies, and mechanical system designs.


• Develop P&IDs, 2D layouts, specifications, detailed drawings, and engineering documentation.


• Ensure designs comply with GMP, ASME BPE, and relevant engineering standards.


• Oversee and mentor junior engineers, providing technical guidance.


• Translate process engineering requirements into robust mechanical solutions.


• Lead mechanical design reviews, DFMEAs, tolerance analyses, and risk assessments.


• Collaborate with fabrication, automation, and process engineering teams.


• Support clients, vendors, and manufacturing teams throughout the project lifecycle. including customer meetings and design reviews.

Your profile

• Bachelor’s degree in Mechanical Engineering or related field.


• 7+ years of mechanical design experience, preferably in biopharma or process industries.


• Proficiency in 2D and 3D CAD modeling, design standards, and engineering best practices.


• Strong understanding of sanitary design, materials, welding, and fabrication methods.


• Experience leading engineering projects and mentoring junior team members.


• Ability to work cross‑functionally and manage technical aspects of client projects.

Work Environment & Physical Requirements

• Hybrid work model with three onsite days per week at the King of Prussia office.


• Travel up to 15%, including domestic and international assignments as needed for project execution, FAT/SAT, or client support.

We offer

• Free Coffee


• competitive PTO & Vacation and Hybrid Work Schedule


• 401K with 5% employer match of annual salary

Under the motto \"Let's Engineer Your Career Together\" we are looking forward to receiving your application!

Your application will
processed by
Nancy Lowell