Senior Mechanical Design Engineer

ZETA; King of Prussia (PA); Hybrid; USD 120,000 - 160,000; Full time

Benefits offered by this job

Free Coffee

Medical, Dental, & Vision Benefits

Competitive PTO & Vacation

401K with 5% employer match

Travel & Training

Job summary

ZETA is a global solutions provider delivering biopharma process systems and automation from planning to commissioning. The Senior Mechanical Design Engineer will lead design activities for upstream/downstream processing, plasma fractionation, ADC manufacturing, and cell therapy projects.

The role requires mentoring junior engineers, conducting design reviews, and ensuring GMP and ASME BPE standards. Hybrid work with on-site days in King of Prussia, with travel as needed.

Qualifications

• Bachelor's degree in Mechanical Engineering or related field.
• 7+ years of mechanical design experience, preferably in biopharma or process industries.
• Proficiency in 2D and 3D CAD modeling and engineering best practices.
• Strong understanding of sanitary design, materials, welding, and fabrication methods.
• Experience leading projects and mentoring junior engineers.
• Ability to work cross-functional and manage client projects.

Responsibilities

• Lead Mechanical Engineering scope throughout the full project lifecycle.
• Lead development of complex 3D models, assemblies, and mechanical system designs.
• Develop P&IDs, 2D layouts, specifications, detailed drawings, and engineering documentation.
• Ensure designs comply with GMP, ASME BPE, and relevant engineering standards.
• Oversee and mentor junior engineers, providing technical guidance.
• Translate process engineering requirements into robust mechanical solutions.
• Lead mechanical design reviews, DFMEAs, tolerance analyses, and risk assessments.
• Collaborate with fabrication, automation, and process engineering teams.
• Support clients, vendors, and manufacturing teams throughout the project lifecycle.

Skills

CAD modeling

Sanitary design

Project leadership

Mentoring

Cross-functional collaboration

Education

Bachelor's in Mechanical Engineering

Tools

2D CAD

3D CAD

P&ID drafting

Job description

ZETA is a globally active solutions provider that supports pharmaceutical and biotech companies in bringing vital medicines - such as insulin, infusions, and cancer treatments - to market faster and more efficiently. As an innovation leader, we combine technical expertise with digital excellence, covering everything from planning and construction to automation and qualification of customized process systems. In addition, we take on full responsibility for complex projects as an EPCMV partner, drive digital transformation, and develop sustainable strategies for decarbonisation.

Senior Mechanical Design Engineer

Location: King of Prussia

Contract: Full-time employee

Start: 30.11.2026

Your tasks

The Senior Mechanical Design Engineer leads mechanical design and engineering activities for ZETA's biopharmaceutical client projects. This role drives the design and development of advanced process systems for upstream processing, downstream purification, plasma fractionation, ADC manufacturing, and cell and gene therapy applications.

The Senior Mechanical Design Engineer serves as a technical leader, guiding junior engineers, leading design reviews, ensuring GMP and ASME BPE compliance, and acting as a key contributor in cross-functional engineering teams.

Key Responsibilities

• Lead Mechanical Engineering scope throughout the full project lifecycle.
• Lead development of complex 3D models, assemblies, and mechanical system designs.
• Develop P&IDs, 2D layouts, specifications, detailed drawings, and engineering documentation.
• Ensure designs comply with GMP, ASME BPE, and relevant engineering standards.
• Oversee and mentor junior engineers, providing technical guidance.
• Translate process engineering requirements into robust mechanical solutions.
• Lead mechanical design reviews, DFMEAs, tolerance analyses, and risk assessments.
• Collaborate with fabrication, automation, and process engineering teams.
• Support clients, vendors, and manufacturing teams throughout the project lifecycle. including customer meetings and design reviews.

Your profile

• Bachelor's degree in Mechanical Engineering or related field.
• 7+ years of mechanical design experience, preferably in biopharma or process industries.
• Proficiency in 2D and 3D CAD modeling, design standards, and engineering best practices.
• Strong understanding of sanitary design, materials, welding, and fabrication methods.
• Experience leading engineering projects and mentoring junior team members.
• Ability to work cross-functional and manage technical aspects of client projects.

Work Environment & Physical Requirements

• Hybrid work model with three onsite days per week at the King of Prussia office.
• Travel up to 15%, including domestic and international assignments as needed for project execution, FAT/SAT, or client support.

We offer

• Free Coffee
• Medical, Dental, & Vision Health Benefits
• competitive PTO & Vacation and Hybrid Work Schedule
• 401K with 5% employer match of annual salary
• Travel & Training