Senior Manager, AI-Driven Operational Excellence

Moderna Therapeutics; Norwood (MA); Hybrid; USD 131,000 - 209,000; Full time

Benefits offered by this job

Competitive healthcare

Well-being programs

Family planning benefits

Generous paid time off

Equity/incentive opportunities

Job summary

Moderna seeks a Senior Manager, Operational Excellence to lead cross-functional improvement efforts across CMC, solving business problems and unlocking value. You will use structured problem solving, digital tools, AI, and emerging tech to rethink how work gets done, experiment, and apply new approaches with practical impact.

Based in our hybrid in-office model, you will partner with teams across the organization, set improvement strategies, coach teams, and drive measurable benefits while

Qualifications

• Bachelor's degree in business, operations, engineering, science, or equivalent.
• Minimum 6 years of experience driving process improvement and change adoption.
• Knowledge of continuous improvement, structured problem solving, performance management.
• Ability to navigate ambiguity and drive sustained value.
• English proficiency in written and spoken.

Responsibilities

• Lead cross-functional improvement initiatives delivering measurable outcomes.
• Define problems, test hypotheses, identify root causes, translate insights into action.
• Set improvement approach for multiple portfolios, select methods accordingly.
• Facilitate cross-functional sessions to align and decide on actions.
• Design future states with standard work, measures, ownership, and change adoption.
• Coach teams in problem framing, root-cause analysis, and benefit assumptions.
• Address cross-process constraints to prevent local optimization.
• Drive benefit realization and ensure sustained results.
• Clarify ownership, approvals, and escalation across processes.
• Share and scale effective improvement approaches across teams.
• Explore and adopt digital tools and AI to improve work and value.

Skills

Structured problem solving

Change management

Stakeholder collaboration

Communication skills

English proficiency

Ambiguity navigation

Education

Bachelor's degree in business/operations/engineering/science or equivalent

Tools

Digital tools & AI

Automation

Low-code/no-code

Job description

Moderna seeks a Senior Manager, Operational Excellence to lead cross-functional improvement efforts across CMC, solving business problems and unlocking value. You will use structured problem solving, digital tools, AI, and emerging tech to rethink how work gets done, experiment, and apply new approaches with practical impact.

Based in our hybrid in-office model, you will partner with teams across the organization, set improvement strategies, coach teams, and drive measurable benefits while