Senior LVV Purification Scientist for CAR-T Analytics

U175 (FCRS = US175) Novartis Institutes for BioMedical Research, Inc.; Cambridge (MA); Presencial; USD 94.000 - 174.000; Jornada completa

Descripción de la vacante

Novartis Institutes for BioMedical Research, Cambridge, MA is seeking a Research Scientist focused on lentiviral vector purification and analytics to advance CAR‑T program development. This lab‑based role involves hands‑on purification, analytics, and cross‑functional collaboration to develop high‑quality viral vectors for next‑generation cell therapies.

You will design experiments, optimize purification processes, and contribute to technology transfer and documentation while working onsite in

Formación

• BS or MS in bioengineering, virology, or related field with relevant lab experience.
• Six years (BS) or four years (MS) of postgraduate experience in viral vector purification.
• BSL2 experience with AAV, lentiviral, or retroviral vector production.
• Proficiency in aseptic technique, cell culture, molecular biology, and analytical testing.
• Expertise in operating different scales of bioreactors for viral vector production.
• Hands-on experience with chromatography and AKTA operation.
• Familiar with downstream processes (depth filtration, ultrafiltration, diafiltration, tangential flow filtration).
• Strong coordination, communication, collaboration, learning agility, and self-motivation.
• Proficiency with Word, Excel, PowerPoint, and GraphPad Prism.
• Excellent oral, written, and interpersonal communication skills.

Responsabilidades

• Hands-on lentiviral vector purification including clarification, chromatography and TFF.
• Execute analytical methods to assess quality of the purified vector.
• Write and review protocols, technical reports, and technology transfer documents.
• Write and review SOPs, instrument procedures, and other lab documents.
• Plan and prioritize work to meet goals while managing multiple research activities.
• Support experimental design, data analysis, and troubleshooting.
• Identify root causes, implement solutions, and verify effectiveness.
• Present scientific data and contribute to discussions.
• Document experimental procedures and processes thoroughly.
• Collaborate across teams, share knowledge, and train team members in technical areas as needed.

Conocimientos

Lentiviral vector purification

Analytical testing

Bioreactor operation

Molecular biology

Data analysis

Communication

Cross-functional collaboration

DOE / Design of Experiments

Training teammates

Educación

BS or MS in bioengineering or virology

Herramientas

AKTA chromatography

Ambr bioreactors

Descripción del empleo

Novartis Institutes for BioMedical Research, Cambridge, MA is seeking a Research Scientist focused on lentiviral vector purification and analytics to advance CAR‑T program development. This lab‑based role involves hands‑on purification, analytics, and cross‑functional collaboration to develop high‑quality viral vectors for next‑generation cell therapies.

You will design experiments, optimize purification processes, and contribute to technology transfer and documentation while working onsite in