CAR-T Discovery Scientist, Next-Gen Cell Therapies

Novartis AG; Cambridge (MA); On-site; USD 109,000 - 202,000; Full time

Job summary

Novartis is seeking a highly motivated PhD scientist to join a multidisciplinary CAR-T discovery team in Cambridge, MA. The role focuses on engineering and evaluating next-generation CAR-T constructs, with hands-on experience in lentiviral CAR design, flow-based analytics, and translational data interpretation.

The successful candidate will collaborate with cross-functional teams, generate high-quality data, and contribute to informing clinical strategies and potential regulatory submissions.

Qualifications

• PhD required in immunology, cell biology, molecular biology, bioengineering, or related field with 1–2 years of relevant research experience.
• Hands-on experience in CAR-T engineering or engineered T-cell approaches.
• Experience with ex vivo cell characterization using multicolor flow cytometry (FACS) and cytokine profiling methods (ELISA, MSD, Luminex).
• Experience designing and generating lentiviral CAR constructs and interpreting functional data.

Responsibilities

• Design and execute research to advance next-generation CAR-T approaches.
• Design, generate, and evaluate complex lentiviral CAR constructs.
• Perform functional testing and optimize CAR-T cells; develop and test analytical methods.
• Engineer cell lines to create models for function and construct prioritization.
• Collaborate across teams to meet timelines with high data quality and integrity.
• Draft technical documents and contribute to regulatory content when needed.
• Present results and recommendations to cross-functional teams and leadership.

Skills

CAR-T engineering

Flow cytometry (FACS)

T-cell culture

Lentiviral constructs

Data interpretation

Education

PhD in immunology or related field

Tools

FACS

ELISA / MSD / Luminex

Job description

Novartis is seeking a highly motivated PhD scientist to join a multidisciplinary CAR-T discovery team in Cambridge, MA. The role focuses on engineering and evaluating next-generation CAR-T constructs, with hands-on experience in lentiviral CAR design, flow-based analytics, and translational data interpretation.

The successful candidate will collaborate with cross-functional teams, generate high-quality data, and contribute to informing clinical strategies and potential regulatory submissions.