Lentiviral Downstream Process Scientist - Cell Therapy

Johnson & Johnson Innovative Medicine; Spring House (PA); On-site; USD 90,000 - 130,000; Full time

Job summary

Johnson & Johnson Innovative Medicine invites applications for a Scientist – Lentiviral Vector Downstream Process Development in Spring House, PA. You will lead development of scalable purification processes for lentiviral products and collaborate across teams to drive data-driven improvements.

The role requires hands-on chromatography, filtration, UF/DF, and process scale-up, plus strong communication and cross-functional teamwork in a regulated biopharma setting.

Qualifications

• BS or MS in Chemical Engineering, Biochemical Engineering, Biological Sciences, Biotechnology, or related field with 2-4 years of industry experience.
• Experience with process development of viral based products.
• Experience in purification process development for biologics, cell and gene therapy, RNA therapeutics, or related viral vector modalities.
• Hands-on experience with chromatography, clarification, depth filtration, UF/DF, sterile filtration, and process scale-up.
• Strong data analysis, experimental design, and technical documentation skills.
• Excellent written and verbal communication skills.
• Ability to work effectively in cross-functional team environments.
• Previous experience with technology transfer of a bioprocess to clinical or commercial GMP manufacturing is strongly preferred
• Occasional weekend work may be required
• Up to 10% domestic and international travel may be required

Responsibilities

• Design and execute downstream process development studies for lentiviral therapeutic products under scientific guidance.
• Conduct purification experiments including chromatography, filtration, UF/DF, and formulation, and automated high-throughput systems.
• Contribute to development of lentiviral processes to continuously improve productivity, quality, and manufacturability.
• Oversee operation and management of downstream equipment, including AKTA systems, TFF systems, and purification skids.
• Perform technology transfer to and collaborate with Johnson & Johnson’s manufacturing sites.
• Support existing and new commercial manufacturing investigations and provide subject matter expert knowledge as part of product life cycle management.
• Apply statistical experimental design, data analytics, and online monitoring and visualization tools to strengthen downstream process understanding.
• Analyze and interpret process data using JMP, MiniTab, Python, Spotfire, or similar platforms.
• Evaluate emerging novel downstream technologies that improve process robustness and development efficiency.
• Collaborate closely with upstream, analytical, formulation, modeling, automation to align study design and deliverables.
• Author technical reports, development summaries, scientific presentations, protocols, and regulatory-supporting documentation.

Skills

Analytical Reasoning

Biochemistry

Chemistry

Manufacturing

CMC

Coaching

Collaboration

Written Expression

Education

BS or MS in Chemical Engineering or related field

Job description

Johnson & Johnson Innovative Medicine invites applications for a Scientist – Lentiviral Vector Downstream Process Development in Spring House, PA. You will lead development of scalable purification processes for lentiviral products and collaborate across teams to drive data-driven improvements.

The role requires hands-on chromatography, filtration, UF/DF, and process scale-up, plus strong communication and cross-functional teamwork in a regulated biopharma setting.