Senior In Vivo Pharmacology Scientist (CRISPR)

Scribe Therapeutics; Alameda (CA); On-site; USD 120,000 - 180,000; Full time

Benefits offered by this job

Health benefits (medical, dental, VSA)

Meaningful equity

Wellness stipend

Learning and development opportunities

Cell stipend

Home office setup stipend

Job summary

Scribe Therapeutics is seeking an experienced Senior Scientist/Principal Scientist in In Vivo Pharmacology to lead in vivo studies and coordinate CRO work from discovery through IND enabling. You will design animal models, analyze data, and contribute to regulatory filings, while mentoring junior scientists.

The role requires hands-on in vivo work, collaboration with CROs, and cross-functional communication in a fast-paced biotech environment in the Bay Area.

Qualifications

• PhD degree in biology, biomedical engineering, pharmacology/toxicology, or related field with 2–4 years of post-graduation experience in industry or academia.
• Experience planning and executing in‑vivo studies, data analysis, and interpretation.
• Previous experience with CRISPR based gene editing is a plus.
• Extensive experience with small laboratory animals and in vivo dosing, bleeding, necropsy, tissue collection.
• Experience planning and executing bioanalytical experiments including ELISA, Western blots, and RT-qPCR.
• Attention to detail, critical analysis of data and troubleshooting abilities.
• Good writing and communication skills; ability to understand and communicate scientific information.
• Highly collaborative working style, and ability to adapt in a fast‑paced environment.
• Ability to work with minimal direction to meet objectives and timelines.

Responsibilities

• Lead the in vivo pharmacology aspect of multiple projects within discovery and development, provide in vivo physiology and pharmacology expertise.
• Propose, plan, coordinate, and supervise study execution at external CROs.
• Develop and implement new animal models to support multiple gene editing targets.
• Plan and conduct in vivo pharmacology studies: formulation and administration of gene editing therapeutics.
• Analyze data from in vivo pharmacology and efficacy studies and perform statistical analysis.
• Communication of experimental plans and data to multiple cross-functional scientific teams.
• Contribute to preparation of study reports, regulatory filings, and project presentations.
• Maintain excellent written documentation of completed experiments (e.g. electronic lab notebook and study reports).
• Mentor early-career scientists on the team.

Skills

In vivo pharmacology

CRO coordination

Animal models

Data analysis

Scientific writing

Team mentorship

CRISPR knowledge

Education

PhD in biology / biomedical engineering / pharmacology or related field

Tools

ELISA

Western blot

RT-qPCR

Job description

Scribe Therapeutics is seeking an experienced Senior Scientist/Principal Scientist in In Vivo Pharmacology to lead in vivo studies and coordinate CRO work from discovery through IND enabling. You will design animal models, analyze data, and contribute to regulatory filings, while mentoring junior scientists.

The role requires hands-on in vivo work, collaboration with CROs, and cross-functional communication in a fast-paced biotech environment in the Bay Area.