Senior Scientist, Biology & Pharmacology — In Vivo/In Vitro

Raven Healthcare Incubator (RA Capital); Boston (MA); On-site; USD 110,000 - 160,000; Full time

Job summary

Raven Healthcare Incubator (RA Capital) seeks a Scientist / Senior Scientist to lead pharmacology across in vitro, ex vivo, and in vivo projects, balancing tissue analysis, assay development, and CRO oversight. The role requires designing rigorous studies, interpreting data, and advancing platform strategies to deliver translational insights.

The candidate will manage sponsor relationships, ensure data integrity, and contribute to publications and regulatory-ready documentation.

Qualifications

• B.S./M.S. or Ph.D. in pharmacology, physiology, cell and molecular biology, or a related discipline.
• Scientist: B.S./M.S. with 8+ years of relevant biopharmaceutical industry experience.
• Senior Scientist: Ph.D. with 5+ years, or B.S./M.S. with 10+ years, of relevant biopharmaceutical industry experience.
• Title will be commensurate with level of qualifications and experience.
• Demonstrated scientific leadership of in vitro and in vivo pharmacology projects in discovery and/or preclinical research and development, including study designs and interpretation that informed project decisions.
• Exceptional scientific aptitude: sharp critical thinking, sound experimental judgment, and the agility to learn new biology quickly across disease areas.
• Strong hands-on skills in tissue processing and analysis (RNA and protein extraction, RT-qPCR, immunoassays, histology/IHC/ISH), mammalian cell culture in cell lines and primary cell models, and cell-based assays, with a record of establishing new methods.
• Track record managing CRO-executed in vivo studies: vendor qualification, protocol alignment, budget and timeline management, and critical evaluation of external data; non-human primate study experience is a plus.
• Hands-on rodent experience (dosing, in-life assessment, terminal collection) sufficient to design realistic protocols and challenge a CRO.
• Sound professional judgment: works independently, prioritizes across concurrent studies, and knows when to elevate.
• Strong quantitative and statistical fluency, including study powering and appropriate analysis of in vivo data.
• Clear scientific writing and communication: protocols, study reports, and data presentations to project teams and leadership.
• Highly organized and detail-oriented, with a record of consistently delivering robust, decision-quality in vitro and in vivo data.
• Experience with oligonucleotide or other nucleic acid therapeutics (tissue exposure, target modulation, PK/PD) and exposure to IND-enabling studies are a plus.

Responsibilities

• Lead pharmacology for early-stage programs, from research planning and study design through data interpretation, helping shape experimental strategy and go/no-go decisions.
• Design rigorous in vivo studies that deliver decision-quality data, with thoughtful dosing, appropriate controls, and adequate statistical power.
• Serve as the day-to-day sponsor contact for CRO-run in vivo studies and analytical vendors, overseeing qualification, scope, budget, timelines, pre-study alignment, in-life monitoring, and troubleshooting, while holding partners to high standards and building strong, productive relationships.
• Manage in vivo sample logistics end to end, including receipt, cataloging, storage, chain of custody, and shipment between CROs and analytical partners.
• Process and analyze tissue samples from in vivo studies to generate target engagement, pharmacodynamic, and efficacy readouts.
• Provide sponsor-side oversight of data integrity, documentation, and animal welfare for external studies, and maintain in vivo records, protocols, and SOPs.
• Develop and run biochemical, molecular, and cell-based assays in cell lines and primary cell models across a range of tissue types, adapting established methods and creating new ones as needed.
• Compile, QC, and interpret in vitro and in vivo data; author study reports; share results with cross-functional teams; and contribute to publications, patents, and presentations

Skills

Oligonucleotide therapeutics

In vivo pharmacology

CRO management

Tissue analysis

RT-qPCR

Education

B.S./M.S. or Ph.D. in pharmacology, physiology, cell and molecular biology

Job description

Raven Healthcare Incubator (RA Capital) seeks a Scientist / Senior Scientist to lead pharmacology across in vitro, ex vivo, and in vivo projects, balancing tissue analysis, assay development, and CRO oversight. The role requires designing rigorous studies, interpreting data, and advancing platform strategies to deliver translational insights.

The candidate will manage sponsor relationships, ensure data integrity, and contribute to publications and regulatory-ready documentation.