Senior In Vivo Pharmacology Associate – CNS Rodent Models

Stoke Therapeutics; Bedford (MA); On-site; USD 98,000 - 110,000; Full time

Benefits offered by this job

Medical insurance

401K with company match

Unlimited vacation time

Tuition assistance

Employee Stock Purchase Program (ESPP)

Job summary

Stoke Therapeutics is seeking a Senior Research Associate in In Vivo Pharmacology to join our preclinical team in Bedford, MA (moving to Waltham, MA). You will execute complex rodent studies using antisense oligonucleotides to restore protein expression, perform neonatal and adult injections, and support PK/PD and efficacy analyses with rigorous data handling.

Required experience includes rodent dose administration routes (SC/IV/IT/ICV), necropsy, anesthesia, and surgical skills.

Qualifications

• BS in Pharmacology or Neuroscience with 4 years experience, MS with 2 years preferred.
• Experience with rodent dose administration routes (SC, IV, IT, ICV).
• Experience with PK/PD studies in rodents.
• Strong necropsy and anesthesia skills.
• Surgical skills including stereotaxic ICV injections.
• Experience with rodent behavioral assays (Open Field, DigiGait, Rotarod).
• Familiarity with Softmouse colony management software.
• Proficiency in data analysis tools (Excel, GraphPad, PowerPoint).

Responsibilities

• Design and execute in vivo rodent studies to advance preclinical pipeline using antisense oligonucleotides to restore protein expression.
• Perform rodent procedures including bolus ICV and IT injections in neonate and adult mice and rats; other routes include SC and IV with blood collection, serial sampling, and tissue collections.
• Perform adult surgical procedures including dosing, anesthesia monitoring and pre/post-op preparations.
• Execute dose-response, time-course, PK/PD, tolerability and efficacy studies.
• Maintain breeding colonies, wean and genotype, and utilize Softmouse to expand colonies for experiments.
• Assess animal phenotypes by implementing behavioral assays like Open Field, DigiGait, Rotarod.
• Prepare tubes for sample collections and perform necropsies and tissue homogenization and molecular biology assays.
• Help analyze and interpret experimental data using appropriate statistical approaches and software.
• Maintain accurate laboratory records, electronic notebooks, study protocols, and data reports.
• Other tasks as assigned

Skills

In vivo rodent studies

Dose administration

PK/PD in rodents

Serial sampling

Necropsy

Anesthesia

Stereotaxic ICV

Behavioral assays

Colony management

Tissue processing

Molecular assays

Softmouse

Data analysis tools

Electronic notebook

Technical writing

Adaptability

Education

B.S. in Pharmacology/Neuroscience

M.S. preferred

Tools

Softmouse

Excel

GraphPad Prism

PowerPoint

Job description

Stoke Therapeutics is seeking a Senior Research Associate in In Vivo Pharmacology to join our preclinical team in Bedford, MA (moving to Waltham, MA). You will execute complex rodent studies using antisense oligonucleotides to restore protein expression, perform neonatal and adult injections, and support PK/PD and efficacy analyses with rigorous data handling.

Required experience includes rodent dose administration routes (SC/IV/IT/ICV), necropsy, anesthesia, and surgical skills.