Senior Engineer - In Silico Modeling & Simulation

BioSpace; Thousand Oaks (CA); On-site; USD 140,000 - 190,000; Full time

Job summary

Amgen is seeking a Senior Engineer to deliver enterprise-level modeling capabilities for prefilled syringes, autoinjectors, and other combination products. You will collaborate with Design Engineering, Quality, Systems Engineering, Manufacturing, and Regulatory teams to develop advanced computational models.

Responsibilities include validating simulations, applying FEA and AI methods, and communicating insights to guide design, verification, and risk mitigation across the product lifecycle.

Qualifications

• Doctorate level degree in Mechanical/ Biomedical/ Civil Engineering focused on computational modeling.
• Masters with 2 years experience in computational modeling and simulation.
• Bachelor with 4 years experience in computational modeling and simulation.
• Associate degree with 8 years engineering experience.
• High school diploma / GED and 10 years of Engineering Experience.

Responsibilities

• Develop, validate, qualify, and deploy advanced computational models for combination products.
• Apply first-principles/analytical modeling, numerical methods, finite element analysis (FEA), surrogate modeling, and AI/ML techniques.
• Develop digital models that improve understanding of device performance, design robustness, and lifecycle behavior.
• Build computational models supporting design verification, manufacturing robustness, root cause investigations, lifecycle management.
• Identify modeling assumptions, requirements, specifications, and acceptance criteria for InSilico evaluation.
• Analyze simulation results and communicate engineering insights to support technical decisions.
• Explore novel computational approaches, automation strategies, AI-enabled engineering methods, and data-driven modeling.
• Develop proof-of-concept modeling solutions for emerging engineering challenges.
• Collaborate with multidisciplinary teams across Product Development, Manufacturing, Quality, Regulatory, Data Science, and Systems Engineering.
• Contribute to project planning, backlog prioritization, Agile/Scrum activities, and continuous improvement.

Skills

Python

MATLAB

C++

Education

Doctorate in Mechanical/Biomedical/Civil Engineering

Masters in Mechanical/Biomedical/Civil Engineering

Bachelor's in Mechanical/Biomedical/Civil Engineering

Associate degree + 8 years engineering experience

High school diploma / GED + 10 years engineering experience

Tools

SIMULIA / 3DEXPERIENCE

ABAQUS

ANSYS

LS-DYNA

COMSOL

Git / GitLab

CI/CD workflows

Model automation

Job description

Amgen is seeking a Senior Engineer to deliver enterprise-level modeling capabilities for prefilled syringes, autoinjectors, and other combination products. You will collaborate with Design Engineering, Quality, Systems Engineering, Manufacturing, and Regulatory teams to develop advanced computational models.

Responsibilities include validating simulations, applying FEA and AI methods, and communicating insights to guide design, verification, and risk mitigation across the product lifecycle.