Principal Scientist - Pharmacometric Modeling & Simulation

Amgen; Thousand Oaks (CA); On-site; USD 180,000 - 240,000; Full time

Benefits offered by this job

Retirement and Savings Plan

Medical, Dental and Vision Insurance

Life and Disability Insurance

Flexible Spending Accounts

Discretionary annual bonus

Stock-based long-term incentives

Generous time-off plans

Flexible work models

Job summary

Amgen is seeking a Principal Scientist in Clinical Pharmacology, Modeling and Simulation to support PK/PD modeling across therapeutic areas. The role involves building pharmacostatistical models, applying Bayesian methods, and contributing to regulatory submissions.

You will work with cross-functional teams to inform dose selection, study design, and development strategy, with opportunities for professional growth and exposure to a broad pipeline.

Qualifications

• Doctorate degree PhD
• PharmD
• MD [and relevant post-doc where applicable] and 2 years of Pharmacokinetics/Pharmacodynamic or statistical modeling experience
• Master’s degree and 5 years of Pharmacokinetics/Pharmacodynamic or statistical modeling experience
• Bachelor’s degree and 7 years of Pharmacokinetics/Pharmacodynamic or statistical modeling experience

Responsibilities

• Building pharmacostatistical models to support Population PK/PD and exposure-response analyses.
• Conducting binary and categorical and time-to-event data analyses, Poisson models, MCMC and Bayesian methods.
• Performing meta-analysis using proprietary and/or literature data.
• Participating in cross-functional project teams and providing scientific input for dose selection and study designs.
• Contributing to clinical pharmacology strategy for the program and project plans.
• Generating modeling reports and contributing to regulatory submission documents.

Skills

Pharmacokinetics/PKPD modeling

Statistical modeling

Modeling software experience

Education

PhD

MD

PharmD

Master’s degree

Bachelor’s degree

Tools

NONMEM

SAS

R

STAN

MATLAB

Job description

Amgen is seeking a Principal Scientist in Clinical Pharmacology, Modeling and Simulation to support PK/PD modeling across therapeutic areas. The role involves building pharmacostatistical models, applying Bayesian methods, and contributing to regulatory submissions.

You will work with cross-functional teams to inform dose selection, study design, and development strategy, with opportunities for professional growth and exposure to a broad pipeline.