Senior Director, Translational Oncology Biomarkers

Brio Group; San Francisco (CA); On-site; USD 260,000 - 380,000; Full time

Job summary

Brio Group is seeking an experienced Senior Director, Translational Medicine to lead clinical biomarker strategy and execution across our oncology portfolio focused on targeted therapies. This senior role will drive biomarker development across the development lifecycle and partner with cross-functional teams to inform patient selection and treatment decisions.

You will oversee biomarker strategy, study design, and companion diagnostics collaboration, using NGS, IHC, PCR, and ctDNA to translate

Qualifications

• PhD required in Cancer Biology, Cell Biology, Molecular Biology, Genomics, or related field.
• 10+ years of biotech/pharma industry experience.
• 6+ years directly in clinical biomarker development within oncology.
• Demonstrated experience developing and executing biomarker strategies for oncology programs.
• Experience with oncogenic signaling pathways.
• Strong understanding of clinical biomarker technologies and molecular assays.

Responsibilities

• Lead development and execution of clinical biomarker strategies across oncology programs.
• Provide translational medicine input into study design, patient selection, and development plans.
• Serve as Translational Medicine representative on cross-functional teams.
• Collaborate with Clinical Development, Biostatistics, Bioinformatics, Regulatory to integrate biomarker objectives into studies.
• Develop biomarker analysis plans with clinical bioinformatics teams.
• Drive strategies for predictive, pharmacodynamic and response biomarkers.
• Partner on implementing clinical assays and diagnostic strategies.
• Apply NGS, IHC, PCR and other molecular approaches to biomarker development.
• Collaborate with discovery teams on translational efforts to understand biology and resistance.
• Support publication and scientific communications related to biomarkers.
• Maintain awareness of emerging science in oncogenic signaling and precision oncology.

Skills

Cross-functional leadership

Biomarker strategy

Translational medicine

Scientific communication

Education

PhD in Cancer Biology / Molecular Biology / Genomics

Tools

NGS

IHC

PCR

ctDNA

Job description

Brio Group is seeking an experienced Senior Director, Translational Medicine to lead clinical biomarker strategy and execution across our oncology portfolio focused on targeted therapies. This senior role will drive biomarker development across the development lifecycle and partner with cross-functional teams to inform patient selection and treatment decisions.

You will oversee biomarker strategy, study design, and companion diagnostics collaboration, using NGS, IHC, PCR, and ctDNA to translate