Senior Director, Translational CNS Pharmacology & Modeling

Scorpion Therapeutics; Indiana (PA); On-site; USD 260,000 - 380,000; Full time

Job summary

Centessa Pharmaceuticals, a Lilly subsidiary, seeks a Senior Director of Clinical Pharmacology to lead translational pharmacology strategies across early to late-stage neuroscience programs.

Responsibilities include developing PK/PD models, dose optimization, biomarker integration, regulatory interactions, and oversight of CROs; this role guides studies from first‑in‑human to post‑marketing and requires strong leadership and collaboration.

Qualifications

• Pharmacology-related doctoral or professional degree required.
• Minimum 10 years of biopharma translational science experience with impact.
• Strong leadership and excellent communication abilities.
• Experience with regulatory submissions and CNS drug development.

Responsibilities

• Develop and execute clinical pharmacology plans for CNS programs.
• Lead model-informed drug development including PK/PD and exposure–response analyses.
• Guide translational pharmacology studies from FIH to post-marketing.
• Represent pharmacology in regulatory interactions and oversight CROs.

Skills

Leadership

Communication

Regulatory interactions

Education

PhD/PharmD/MD in pharmacology-related field

10+ years biopharma translational science experience

Tools

PK/PD modeling

NONMEM

R

Phoenix WinNonlin

Exposure–response analyses

Job description

Centessa Pharmaceuticals, a Lilly subsidiary, seeks a Senior Director of Clinical Pharmacology to lead translational pharmacology strategies across early to late-stage neuroscience programs.

Responsibilities include developing PK/PD models, dose optimization, biomarker integration, regulatory interactions, and oversight of CROs; this role guides studies from first‑in‑human to post‑marketing and requires strong leadership and collaboration.