Senior Director, DMPK Project Leader

Scorpion Therapeutics; Boston (MA); On-site; USD 180,000 - 260,000; Full time

Job summary

Centessa Pharmaceuticals is seeking a Senior Director, DMPK Project Leader to drive nonclinical PK activities and support CNS drug development. The role will oversee PK, ADME, biotransformation, bioanalytical, and toxicokinetic studies within a dynamic, cross-functional team.

The successful candidate will have a Ph.D. in a relevant field, 10+ years in biotech/pharma, and expertise in DMPK, regulatory submissions (NDAs), and PK modeling tools such as Phoenix WinNonlin.

Qualifications

• Ph.D. required in a related field.
• 10+ years of industry experience in biotech/pharma.

Responsibilities

• Oversee nonclinical PK experiments.
• Support compound profiling and project progression.
• Lead NDA filings for DMPK.
• Analyze and communicate PK/toxicokinetic data to cross-functional teams.
• Coordinate with discovery and development teams.

Skills

DMPK sciences

Drug discovery & development

Regulatory submissions

Cross-functional communication

Education

Ph.D. in Pharmaceutical Sciences, Pharmacology, or related field

Tools

Phoenix WinNonlin

Job description

Role: Senior Director, DMPK Project Leader at Centessa Pharmaceuticals

leading DMPK activities to support CNS drug development, including PK, ADME, biotransformation, bioanalytical, and toxicokinetic studies.

Responsibilities

• oversee nonclinical PK experiments
• support compound profiling and project progression
• lead NDA filings for DMPK
• analyze and communicate PK/toxicokinetic data to cross-functional teams
• coordinate with discovery and development teams

Requirements

• Ph.D. in Pharmaceutical Sciences, Pharmacology, or related field
• 10+ years industry experience in biotech/pharma
• expertise in DMPK sciences, drug discovery, and development processes
• proficiency with PK modeling tools like Phoenix WinNonlin
• experience supporting GLP studies and regulatory submissions (NDAs)

High Value

• CNS drug candidates
• DMPK sciences
• NDA submission
• PK modeling
• GLP
• nonclinical/toxicokinetic studies

Work Setup

US-based, with occasional travel.