Senior Director, Biomarker & Translational Sciences Leader

Seismic Therapeutic; Watertown (MA); On-site; USD 220,000 - 280,000; Full time

Job summary

Seismic Therapeutic in Watertown, MA, seeks an experienced biomarker leader to build and run the Biomarker and Translational Sciences group, reporting to CSO, overseeing PK, immunogenicity, receptor occupancy, and PD assays across discovery to IND-enabling stages.

You will bridge Research and Clinical Development, manage CROs, lead assay transfer, validation, and sample management, and collaborate with external partners to drive data that informs development decisions; travel to CROs and

Qualifications

• PhD in immunology, biochemistry, or related field.
• 12+ years of post-doctoral/group leadership in biotech/pharma.
• Experience leading biomarker and translational sciences programs.
• Proven track record delivering IND- and clinic-ready bioanalytical assays.
• Experience managing bioanalytical CROs and vendors.

Responsibilities

• Build and lead the Biomarker and Translational Sciences group.
• Define bioanalytical strategy for IND-enabling and clinical studies.
• Oversee assay development for PK, immunogenicity, and biomarker analyses.
• Collaborate with CROs, labs, and internal teams to align on strategy.
• Ensure QA and regulatory compliance (GLP, GCP).

Skills

Immunology expertise

Leadership of scientific teams

Biomarker assay development

Regulatory knowledge GLP/GCP

CRO/vendor oversight

Communication skills

Education

PhD in immunology, biochemistry, or related discipline

Tools

Flow cytometry

Mass spectrometry

Proteomics

Transcriptomics

Job description

Seismic Therapeutic in Watertown, MA, seeks an experienced biomarker leader to build and run the Biomarker and Translational Sciences group, reporting to CSO, overseeing PK, immunogenicity, receptor occupancy, and PD assays across discovery to IND-enabling stages.

You will bridge Research and Clinical Development, manage CROs, lead assay transfer, validation, and sample management, and collaborate with external partners to drive data that informs development decisions; travel to CROs and