Senior Crystallization Scientist – Process Dev & Scale-Up

Merck & Co.; Rahway (NJ); On-site; USD 117,000 - 184,200; Full time

Job summary

Merck & Co. seeks a crystallization subject matter expert in the Chemical Engineering Research & Development group to develop isolation processes for APIs and drug substance intermediates.

You will use PAT and process modeling, mentor colleagues, and work across cross-functional teams to advance crystallization technologies from bench to production scale. The role emphasizes safety and quality, cGMP compliance, and potential external supplier management, with ongoing development of drying,

Qualifications

• The position requires BS and/or MS in Chemical/Biochemical Engineering (or comparable) plus at least 5 years of relevant work experience in crystallization process development, or a PhD in Chemical/Biochemical Engineering (or comparable).

Responsibilities

• Develop isolation processes delivering desired solid-state properties, purity and yield for clinical programs across pipelines.
• Perform hands-on process development and scale-up from benchtop to commercial manufacturing sites.
• Mentor colleagues and collaborate across API form and physical attributes decisions.
• Comply with cGMPs, participate in risk assessments and deviation investigations, and adhere to GDocP.

Skills

Crystallizations

DOE

Process Models

Process Scale Up

cGMP Regulations

Chemical Engineering

Chemical Synthesis

Chemical Technology

Chromatographic Techniques

Deviation Investigations

Distillations

GMP

Interdisciplinary Collaboration

Collaborative Communications

Small Molecule Synthesis

Education

BS/MS in Chemical/Biochemical Engineering (or comparable)

PhD in Chemical/Biochemical Engineering (or comparable)

Job description

Merck & Co. seeks a crystallization subject matter expert in the Chemical Engineering Research & Development group to develop isolation processes for APIs and drug substance intermediates.

You will use PAT and process modeling, mentor colleagues, and work across cross-functional teams to advance crystallization technologies from bench to production scale. The role emphasizes safety and quality, cGMP compliance, and potential external supplier management, with ongoing development of drying,