Lead Crystallization Process Engineer

BioSpace; Indianapolis (IN); On-site; USD 129,000 - 209,000; Full time

Job summary

Lilly in Indianapolis is seeking a crystallization engineer to own the design and optimization of crystallization processes across small molecules and peptides. You will work with chemists, analysts, formulation and process engineers to deliver robust, scalable APIs for clinical materials.

You will apply cGMP/ICH principles, lead technology transfer to pilots and CMOs, mentor junior staff, publish and present findings, and contribute to regulatory filings.

Qualifications

• PhD in Chemical Engineering required.
• MSc in Chemical Engineering with 7+ years of experience.
• BSc in Chemical Engineering with 10+ years of experience.

Responsibilities

• Lead crystallization process design end-to-end — including nucleation kinetics, growth, solubility controls, and scale-up to clinical materials.
• Innovate across crystallization strategies: cooling, antisolvent, reactive, and seeded crystallization with PAT tools and DoE to build deep process understanding.
• Be the go-to crystallization expert on project teams, driving particle engineering strategy and contributing to regulatory filings (IND, IMPD, NDA).
• Bridge bench to plant to patient by partnering with formulation, analytical, and manufacturing teams to translate APIs to drug products and lead scale-up and technology transfer to pilot plants and CMOs.
• Grow as a scientific leader by mentoring talent, publishing, and presenting in venues like AIChE and ACS.

Skills

Crystallization engineering

Process design

Regulatory awareness

Education

PhD in Chemical Engineering

MSc in Chemical Engineering +7 years of experience

BSc in Chemical Engineering +10 years of experience

Tools

Population balance modeling software

Thermodynamic solubility modeling

Job description

Lilly in Indianapolis is seeking a crystallization engineer to own the design and optimization of crystallization processes across small molecules and peptides. You will work with chemists, analysts, formulation and process engineers to deliver robust, scalable APIs for clinical materials.

You will apply cGMP/ICH principles, lead technology transfer to pilots and CMOs, mentor junior staff, publish and present findings, and contribute to regulatory filings.