Senior Crystallization Scientist & Process Development

Merck & Co.; Rahway (NJ); On-site; USD 142,400 - 224,100; Full time

Benefits offered by this job

Annual bonus

Long-term incentive

Comprehensive benefits

Job summary

Merck & Co. is seeking a crystallization subject matter expert to drive isolation processes for APIs and drug substance intermediates.

You will work hands-on from benchtop to pilot/production scales, applying PAT, modeling, and advanced analytics to optimize purity, yield and solid-state outcomes. The role demands strong collaboration across drug substance/product teams, mentoring colleagues, and adherence to cGMP and GDocP.

Qualifications

• BS/MS: 8+ years post-grad experience in crystallization process development.
• PhD: 3+ years post-PhD experience in crystallization and solid-state analysis.
• Experience with crystallization process development and solid-state analysis.
• Experience with process scale-up / technology transfer to pilot or production scale.
• Knowledge of cGMP in pharmaceutical development and manufacturing.

Responsibilities

• Develop isolation processes to achieve desired solid-state properties, purity and yield.
• Apply PAT and process modeling to enhance crystallization development.
• Mentor colleagues and drive cross-functional collaboration in API form decisions.
• Ensure safety, quality and compliance with cGMP and GDocP.

Skills

Crystallization theory

Process analytical technology

Cross-functional collaboration

Excellent communication

Dry and wet milling

Scale-up & tech transfer

cGMP knowledge

Problem solving

Drug substance processing

PAT & modeling

Education

BS/MS in Chemical/Biochemical Engineering

PhD in Chemical/Biochemical Engineering

Tools

FTIR

FBRM

Raman

Image analysis

Job description

Merck & Co. is seeking a crystallization subject matter expert to drive isolation processes for APIs and drug substance intermediates.

You will work hands-on from benchtop to pilot/production scales, applying PAT, modeling, and advanced analytics to optimize purity, yield and solid-state outcomes. The role demands strong collaboration across drug substance/product teams, mentoring colleagues, and adherence to cGMP and GDocP.