Senior Computational Biologist — Peptide Therapeutics

Endevica Bio; Illinois; On-site; USD 110,000 - 165,000; Full time

Benefits offered by this job

Health insurance

Vision insurance

Dental insurance

Flexible spending accounts

Health savings accounts

Retirement plan

Equity incentive

Paid time off

Job summary

Endevica Bio, a Northbrook, IL–based clinical-stage biotechnology company, is seeking a Senior Scientist, Computational Biology to support target validation, peptide structure-activity analysis, and translational data efforts across our discovery and development pipeline.

An ideal candidate has extensive training in bioinformatics or computational biology, experience analyzing large datasets, and the ability to bridge computation and biology across projects.

Qualifications

• MS or PhD in bioinformatics, computational biology, chemistry, computer science, statistics, or engineering, or equivalent experience.
• Experience analyzing large, complex datasets and identifying appropriate analytical methods.
• Proficiency in Python (Biopython, pandas, NumPy, scikit-learn) and R for biological data analysis.
• Hands-on experience with protein/peptide structural analysis and modeling tools such as AlphaFold, PyMol, Rosetta.
• Familiarity with reproducible pipelines and containerization (Git, Docker).
• Experience querying public databases (UniProt, PDB, ChEMBL, PubChem).
• Ability to communicate complex findings to cross-functional teams.

Responsibilities

• Plan and execute analysis of multi-dimensional experimental datasets, identifying analytical approaches and troubleshooting data quality.
• Mine and integrate genomic, transcriptomic, and structural databases to identify targets or biomarkers.
• Develop and maintain computational pipelines for peptide sequence analysis and SAR modeling.
• Support lead optimization with sequence/structure-based analysis of peptide analogs.
• Build dashboards and reporting tools to visualize complex datasets for cross-functional teams.
• Ensure workflows are reproducible, well-documented, and version-controlled.
• Evaluate new computational methods and databases relevant to peptide therapeutics.
• Collaborate with Discovery, Development, and Clinical teams to align analyses with milestones.

Skills

Python (Biopython, pandas, NumPy, scik

Education

MS or PhD in bioinformatics or computational biology

Tools

Git

Docker

RDKit

PyMol

Rosetta

UniProt

PDB

ChEMBL

Job description

Endevica Bio, a Northbrook, IL–based clinical-stage biotechnology company, is seeking a Senior Scientist, Computational Biology to support target validation, peptide structure-activity analysis, and translational data efforts across our discovery and development pipeline.

An ideal candidate has extensive training in bioinformatics or computational biology, experience analyzing large datasets, and the ability to bridge computation and biology across projects.