Senior Scientist, Computational Biology — AI-Driven Data Analytics

Denali Therapeutics Inc; South San Francisco (CA); On-site; USD 147,000 - 191,000; Full time

Benefits offered by this job

401k

Healthcare coverage

ESPP

Job summary

Denali Therapeutics Inc is seeking an experienced computational biologist to define and guide computational biology efforts across Discovery. You will work with scientists to advance projects from early target validation through IND-enabling studies, leveraging analysis of high-dimensional data and external partners as needed.

The role combines hands-on analysis with strategic oversight, shaping analytical approaches, developing tools, and contributing to regulatory filings and publications.

Qualifications

• PhD in a relevant field such as Computational Biology, Epidemiology, Neuroscience, Statistics, or similar, with 3+ years of industry experience.
• Proven track record analyzing single-cell/single-nucleus RNA-seq data with publications and solid statistical methods.
• Experience with high-dimensional data types (proteomics, mass spectrometry, human genetics) is a plus.
• Strong experience in R or Python for analysis of high-dimensional biological data.
• Knowledge of version control (Git) and report-generation tools (R Markdown, Quarto).
• Experience building dashboards (Shiny) is a plus.

Responsibilities

• Serve as SME for analysis of high-dimensional data, including bulk and single-cell/nucleus transcriptomics.
• Collaborate with Discovery scientists to design, analyze, and interpret in vitro and in vivo experiments.
• Perform rigorous, reproducible analyses across transcriptomic and genomic datasets.
• Develop and extend internal computational tools and oversee external analysis efforts.
• Independently define analytical approaches and validate results with minimal oversight.
• Incorporate AI-assisted analysis while evaluating outputs for accuracy and rigor.
• Apply best practices for code and data management, including workflows and version control.
• Communicate results to cross-functional teams and contribute to filings and publications.

Job description

Denali Therapeutics Inc is seeking an experienced computational biologist to define and guide computational biology efforts across Discovery. You will work with scientists to advance projects from early target validation through IND-enabling studies, leveraging analysis of high-dimensional data and external partners as needed.

The role combines hands-on analysis with strategic oversight, shaping analytical approaches, developing tools, and contributing to regulatory filings and publications.