Senior Scientist, Computational Biology

Endevica Bio; Illinois; On-site; USD 110,000 - 165,000; Full time

Benefits offered by this job

Health insurance

Vision insurance

Dental insurance

Flexible spending accounts

Health savings accounts

Retirement plan

Equity incentive

Paid time off

Job summary

Endevica Bio, a Northbrook, IL–based clinical-stage biotechnology company, is seeking a Senior Scientist, Computational Biology to support target validation, peptide structure-activity analysis, and translational data efforts across our discovery and development pipeline.

An ideal candidate has extensive training in bioinformatics or computational biology, experience analyzing large datasets, and the ability to bridge computation and biology across projects.

Qualifications

• MS or PhD in bioinformatics, computational biology, chemistry, computer science, statistics, or engineering, or equivalent experience.
• Experience analyzing large, complex datasets and identifying appropriate analytical methods.
• Proficiency in Python (Biopython, pandas, NumPy, scikit-learn) and R for biological data analysis.
• Hands-on experience with protein/peptide structural analysis and modeling tools such as AlphaFold, PyMol, Rosetta.
• Familiarity with reproducible pipelines and containerization (Git, Docker).
• Experience querying public databases (UniProt, PDB, ChEMBL, PubChem).
• Ability to communicate complex findings to cross-functional teams.

Responsibilities

• Plan and execute analysis of multi-dimensional experimental datasets, identifying analytical approaches and troubleshooting data quality.
• Mine and integrate genomic, transcriptomic, and structural databases to identify targets or biomarkers.
• Develop and maintain computational pipelines for peptide sequence analysis and SAR modeling.
• Support lead optimization with sequence/structure-based analysis of peptide analogs.
• Build dashboards and reporting tools to visualize complex datasets for cross-functional teams.
• Ensure workflows are reproducible, well-documented, and version-controlled.
• Evaluate new computational methods and databases relevant to peptide therapeutics.
• Collaborate with Discovery, Development, and Clinical teams to align analyses with milestones.

Skills

Python (Biopython, pandas, NumPy, scik

Education

MS or PhD in bioinformatics or computational biology

Tools

Git

Docker

RDKit

PyMol

Rosetta

UniProt

PDB

ChEMBL

Job description

Endevica Bio is a clinical-stage biotechnology company north of Chicago. We design novel peptide-based medicines for complex diseases where patients still have too few good options. Our team brings together deep expertise in peptide design, biology, and drug development to move promising ideas toward the clinic. There is ambitious science happening here, and there is a real sense that the work we do today could meaningfully change patients’ lives tomorrow.

We’re a very small company. This is intentional. A lean team keeps us creative, collaborative, and closely connected to the science. Everyone knows what the company is working toward, everyone has a voice, and no one is limited to a narrow corner of the job description. Work moves quickly, priorities evolve, and good ideas become real experiments without layers of decision-making. For the right person , — someone curious, open-minded, and excited to help build a biotechnology company while building its future medicines—it is a rare and rewarding place to work.

We are seeking a Senior Scientist, Computational Biology to support target validation, peptide structure-activity analysis, and translational data efforts across our discovery and development pipeline.

An ideal candidate will have extensive training in bioinformatics, computational biology, or a closely related discipline. Experience analyzing large and complex experimental datasets is required. We are particularly interested in scientists who can move fluidly between computation and biology; identifying meaningful patterns, generating testable hypotheses, connecting data to molecular mechanisms, and using quantitative approaches to help guide the next experiment. Experience with protein, peptide, pharmacology, structural biology, omics, or drug-discovery datasets is highly valued.

Responsibilities

• Plan and execute analysis of large, multi-dimensional experimental datasets (e.g., high-throughput screening, omics, or structural datasets), identifying appropriate analytical approaches and troubleshooting data quality issues as they arise.
• Mine and integrate public and proprietary genomic, transcriptomic, and structural databases to identify, prioritize, and characterize novel targets or biomarkers.
• Develop and maintain computational pipelines for peptide sequence analysis and structure activity relationship modeling in collaboration with medicinal chemistry.
• Support lead optimization efforts by providing sequence and structure-based analysis of peptide analogs, complementing existing cheminformatics workflows (RDKit, Spotfire).
• Build internal dashboards and reporting tools to visualize complex biological datasets for cross-functional teams and leadership.
• Ensure computational workflows are reproducible, well-documented, and version-controlled, following best practices for data integrity.
• Evaluate and recommend new computational methods, tools, and databases relevant to peptide therapeutics and receptor pharmacology as the field evolves.
• Collaborate cross-functionally with Discovery, Development, and Clinical teams to align computational analyses with scientific milestones.

Job Requirements

• MS or PhD in bioinformatics, computational biology, chemistry, computer science, statistics, mathematics, engineering or a closely related discipline – or an equivalent amount of industry or research experience.
• Demonstrated experience analyzing large, complex experimental datasets, with the ability to identify appropriate analytical methods and troubleshoot data quality issues
• Demonstrated proficiency in Python (Biopython, pandas, NumPy, scikit-learn) and R for biological data analysis.
• Hands-on experience with protein/peptide structural analysis and modeling tools, preferred (e.g., AlphaFold, PyMol, Rosetta, or equivalent structure prediction and visualization software).
• Familiarity with workflow/pipeline management frameworks for reproducible computational analysis.
• Experience querying and integrating public biological databases (UniProt, PDB, ChEMBL, PubChem) into research workflows.
• Proficiency with version control (Git) and containerization (Docker) to support reproducible, collaborative research.
• Ability to communicate complex computational findings clearly to cross-functional teams including chemistry, pharmacology and executive stakeholders..
• Record of scientific contribution demonstrated through peer-reviewed publications, conference presentations, or equivalent research output.

This is a full-time, on-site position in Northbrook, IL.

The expected salary range for the position is $110,000 to $165,000. Full-time employees may also be eligible for an annual bonus based on company and individual performance.

Endevica Bio also provides eligible employees with an opportunity to enroll in a variety of benefit programs, generally including health, vision, and dental insurance, flexible spending accounts, health savings accounts, retirement savings plans, life, and disability insurance programs, equity incentive plans, and paid and unpaid time away from work.

Endevica Bio isan equal employment opportunity employer. We evaluate applicants without regard to race, religion, color, national origin, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, gender expression, transgender status, sexual stereotypes, age, status as a protected veteran, status as an individual with a disability, or any other legally protected characteristics. We also consider applicants with criminal histories, consistent with applicable federal, state and local law.

Endevica Bio is committed to working with and providing reasonable accommodations to individuals with disabilities. If you need a reasonable accommodation because of a disability for any part of the employment process, please send an e-mail [e-mail] let us know the nature of your request and your contact information.