Senior Clinical Science Director – MASH Trials

Madrigal; Conshohocken (Montgomery County); On-site; USD 288,000 - 352,000; Full time

Benefits offered by this job

Equity

Medical insurance

Dental

Vision

Life/disability insurance

401(k) with employer match

Flexible PTO

Job summary

Madrigal is a biopharmaceutical company focused on developing therapies for MASH. The Senior Clinical Development role leads protocol design, regulatory submissions, and cross‑functional trial execution to advance programs through clinical stages.

Strong communication, collaboration, and project management are essential for success in a fast-paced biotech environment. The role requires advanced life sciences degrees and 12+ years of clinical development experience, with preference for liver

Qualifications

• Excellent verbal and written communication skills.
• Collaborative mindset with strong organizational and project management abilities.

Responsibilities

• Design and develop clinical trial protocols with scientific rationale, objectives, endpoints, and eligibility criteria.
• Author or review investigator brochures, informed consent forms, CSRs, and regulatory submissions.
• Provide scientific input during trial execution, including protocol amendments and data reviews.
• Collaborate with clinical operations, data management, biostatistics, and medical writing to ensure trial quality and data integrity.
• Conduct data reviews and support data interpretation with biostatistics and medical team.
• Prepare documents for regulatory submissions and health authority meetings.

Skills

Verbal communication

Written communication

Project management

Cross-functional collaboration

Organizational skills

Education

PhD/MD/PharmD

Master’s degree with relevant experience

Job description

Madrigal is a biopharmaceutical company focused on developing therapies for MASH. The Senior Clinical Development role leads protocol design, regulatory submissions, and cross‑functional trial execution to advance programs through clinical stages.

Strong communication, collaboration, and project management are essential for success in a fast-paced biotech environment. The role requires advanced life sciences degrees and 12+ years of clinical development experience, with preference for liver