Senior Biotransformation Scientist: Metabolite ID & DMPK

Bristol-Myers Squibb Co; Princeton (NJ); In loco; USD 122.000 - 147.000; Tempo pieno

Vantaggi offerti da questo lavoro

Flexible Time Off (FTO)

11 paid holidays

Paid vacation

Stock opportunities

Descrizione del lavoro

Bristol Myers Squibb is seeking a creative, self-motivated Senior Scientist to join the DMPK group in Princeton, NJ. You will support biotransformation experiments in discovery, providing subject matter expertise in metabolite identification and metabolism studies across in vitro and in vivo platforms.

The role offers collaboration across multidisciplinary teams, mentoring of junior scientists, and opportunities to contribute to program strategy and data interpretation using advanced mass

Competenze

• Bachelor’s degree in chemical biology, biochemistry, bioanalytical chemistry, cell biology or a related discipline with 7+ years of relevant academic and/or industry experience.
• Master’s degree with 5+ years of relevant experience.
• Ph.D. or equivalent advanced degree with 2+ years of relevant experience.
• Hands-on experience in small-molecule biotransformation, drug‑metabolizing enzymes, metabolite identification or related ADME sciences, including operating and troubleshooting LC‑MS/MS and high‑resolution mass spectrometry instrumentation.
• Ability to independently design experiments, interpret and summarize data, and communicate conclusions and recommendations clearly.
• Excellent oral and written communication skills and a track record of working collaboratively across disciplines.
• Working knowledge of organic or medicinal chemistry relevant to metabolite identification and structural interpretation.
• Experience applying computational tools for metabolite prediction (MassMetasite/ONIRO, StarDrop) and data‑analysis/summary tools such as Excel, PowerPoint and GraphPad Prism, with interest in expanding AI‑enabled approaches to data interpretation and hypothesis generation.
• A track record of scientific achievement demonstrated via publication record.

Mansioni

• Provide scientific and technical expertise in small-molecule biotransformation and metabolite identification.
• Design, conduct, interpret and report high-quality mechanistic in vitro and in vivo metabolism studies to characterize metabolic pathways.
• Use experimental data, literature and mechanistic reasoning to define next steps and troubleshoot studies.
• Operate and troubleshoot LC-MS/MS and high-resolution mass spectrometry platforms; contribute to new assays and data-analysis approaches.
• Contribute to program science and strategy, lead discussions and present recommendations.
• Collaborate across DMPK and partner functions, mentoring junior scientists as appropriate.

Conoscenze

Biotransformation

Metabolite identification

Experimental design

Data interpretation

Cross-disciplinary collaboration

Oral/written communication

AI-enabled data interpretation

Formazione

Bachelor’s degree in chemical biology/biochemistry/related

Master’s degree with 5+ years experience

Ph.D. with 2+ years experience

Strumenti

LC-MS/MS

High‑resolution mass spectrometry

MassMetaSite/ONIRO

StarDrop

Excel

PowerPoint

GraphPad Prism

Descrizione del lavoro

Bristol Myers Squibb is seeking a creative, self-motivated Senior Scientist to join the DMPK group in Princeton, NJ. You will support biotransformation experiments in discovery, providing subject matter expertise in metabolite identification and metabolism studies across in vitro and in vivo platforms.

The role offers collaboration across multidisciplinary teams, mentoring of junior scientists, and opportunities to contribute to program strategy and data interpretation using advanced mass