Senior Scientist, Biotransformation

Bristol Myers Squibb; Princeton (NJ); On-site; USD 122,000 - 147,000; Full time

Benefits offered by this job

Comprehensive benefit plans

Flexible Time Off (FTO)

Paid vacation and holidays

Global Shutdown between Christmas and

Job summary

Bristol Myers Squibb in Princeton, NJ seeks a Senior Scientist, Biotransformation to advance discovery through metabolite identification and biotransformation studies.

You will lead in vitro/in vivo metabolism work, collaborate with DMPK and partner teams, and mentor junior scientists in a multidisciplinary setting.

Qualifications

• Bachelor’s degree in chemical biology, biochemistry, bioanalytical chemistry, cell biology or related field with 7+ years experience; or Master’s with 5+; or PhD with 2+ years.
• Hands-on experience in small-molecule biotransformation, drug-metabolizing enzymes, metabolite identification or related ADME sciences, including LC-MS/MS and HRMS.
• Ability to design experiments, interpret data, and communicate conclusions clearly; strong collaboration skills.
• Working knowledge of organic/medicinal chemistry relevant to metabolite identification and structural interpretation.
• Experience with computational tools for metabolite prediction (MassMetasite/ONIRO, StarDrop) and data-analysis tools (Excel/PowerPoint/GraphPad).
• Track record of scientific achievement evidenced by publications.

Responsibilities

• Provide scientific and technical expertise in biotransformation and metabolite ID; design and interpret metabolism studies.
• Define next steps using data, literature, and reasoning; troubleshoot complex metabolism questions.
• Operate LC-MS/MS and HRMS platforms; contribute to new assays and data analysis.
• Lead discussions, mentor junior scientists, and collaborate across DMPK and partner functions.

Skills

Small-molecule biotransformation

LC-MS/MS operation

Mass spectrometry data analysis

Interdisciplinary collaboration

Education

Bachelor’s or higher in chemical biology/biochemistry

Ph.D. or equivalent with experience (optional)

Tools

LC-MS/MS

High-resolution MS

MassMetasite/ONIRO

StarDrop

Excel

PowerPoint

GraphPad Prism

Job description

At Bristol Myers Squibb, our employees often ask, “Who are you working for?”—a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits. This is work that transforms the lives of patients, and the careers of those who do it.

Summary

Bristol Myers Squibb (BMS) is seeking a creative, self-motivated scientist with strong problem-solving skills to join our Drug Metabolism and Pharmacokinetics (DMPK) group as a Senior Scientist in Biotransformation at our Princeton, NJ site. The role is within the Pharmaceutical Candidate Optimization (PCO) group, a multidisciplinary organization that provides DMPK, toxicology, pharmaceutics and bioanalytical expertise to advance discovery programs. In this role, the successful candidate will primarily support biotransformation experiments in the discovery stage, providing subject matter expertise in metabolite identification.

Responsibilities

• Provide scientific and technical expertise in small-molecule biotransformation and metabolite identification; design, conduct, interpret and report high-quality mechanistic in vitro and in vivo metabolism studies to characterize metabolic pathways, evaluate metabolic kinetics and address discovery program questions.
• Use experimental data, scientific literature and mechanistic reasoning to define next steps, troubleshoot studies and resolve complex or ambiguous metabolism questions.
• Operate and troubleshoot LC-MS/MS and high-resolution mass spectrometry platforms, and contribute to the development and implementation of new assays, technologies and data-analysis approaches.
• Contribute to program science and strategy, lead scientific discussions and present clear recommendations in multidisciplinary meetings; collaborate across DMPK, partner functions and BMS sites, and provide technical guidance or mentoring to junior scientists as appropriate.

Education, Experience, And Skill Requirements

• Bachelor’s degree in chemical biology, biochemistry, bioanalytical chemistry, cell biology or a related discipline with 7+ years of relevant academic and/or industry experience; or Master’s degree with 5+ years of relevant experience; or Ph.D. or equivalent advanced degree with 2+ years of relevant experience.
• Hands‑on experience in small‑molecule biotransformation, drug‑metabolizing enzymes, metabolite identification or related ADME sciences, including operating and troubleshooting LC‑MS/MS and high‑resolution mass spectrometry instrumentation.
• Ability to independently design experiments, interpret and summarize data, and communicate conclusions and recommendations clearly; excellent oral and written communication skills and a track record of working collaboratively across disciplines.
• Working knowledge of organic or medicinal chemistry relevant to metabolite identification and structural interpretation.
• Experience applying computational tools for metabolite prediction (MassMetasite/ONIRO, StarDrop) and data‑analysis/summary tools such as Excel, PowerPoint and GraphPad Prism, with interest in expanding AI‑enabled approaches to data interpretation and hypothesis generation.
• A track record of scientific achievement demonstrated via publication record.

We hire for skills and capabilities, not just credentials – if this role excites you, but doesn’t perfectly match your resume, we encourage you to apply anyway.

Compensation Overview

Princeton - NJ - US: $121,500 - $147,228

The starting pay range(s) listed above is for full-time employees (FTE). You may also be eligible for additional discretionary incentive cash and stock opportunities. We determine starting pay thoughtfully – carefully considering the nature of the role, required skills, work location, schedule and the knowledge and experience you bring. Final compensation is guided by pay equity principles and applicable employment laws. Compensation programs are reviewed on an ongoing basis and may be adjusted over time to reflect evolving market factors, and individual, team or Company performance.

Benefits

• Subject to the terms and conditions of the applicable plans then in effect, you may be eligible to participate in our comprehensive benefit plans – including wellbeing support, retirement and financial protection benefits, and insurance offerings (medical, dental, vision, life and disability).
• U.S.-based exempt employees are eligible for Flexible Time Off (FTO), which provides paid time off without a set accrual limit, subject to manager approval, along with 11 paid company holidays each year.
• Non-exempt employees, RayzeBio employees, and employees located in Puerto Rico receive 160 hours of paid vacation annually for new hires (subject to manager approval), 11 paid company holidays, and 3 optional holidays.
• Depending on eligibility, employees may also have access to additional time-off benefits, including paid sick leave, up to two paid volunteer days per year, summer hours flexibility, and leaves of absence for medical, personal, parental, caregiver, bereavement, or military needs. Eligible employees also enjoy an annual Global Shutdown between Christmas Day and New Year's Day.
• U.S.-based job seekers can explore full benefit offerings at https://careers.bms.com/benefits

How We Work

Where you work matters – because collaboration, innovation and patient impact happen in many settings. Our roles are structured across four work models: site-essential, site-by-design, field-based and remote-by-design. The model assigned to this role is based on its core responsibilities. Learn more at https://careers.bms.com/ways-of-working.

Supporting People With Disabilities

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to [e-mail]. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

Candidate Rights

BMS will consider qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

For roles based in Los Angeles County only: If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/

Data Protection

We will never request payments, financial information, or social security numbers during our application or recruitment process. Learn more about protecting yourself at https://careers.bms.com/fraud-protection.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

If this posting is missing required information required by local law or incorrect, contact BMS at [e-mail] the Job Title and Requisition number. Do not send application-related inquiries to this email. To check your application status, please login to your Candidate Home Account.

R1607184 : Senior Scientist, Biotransformation