Senior Biologics Scientist: Purification & Analytics

ImmunEdge; Redwood City (CA); On-site; USD 106,000 - 139,000; Full time

Benefits offered by this job

Annual bonus plan

Equity

Health insurance

401k plan

FSA plans

Employee Assistance Plan

Paid time off

Job summary

ImmunEdge is seeking a Senior Research Associate/Scientist to join the protein purification and analytics team in the Biotherapeutics Department. You will own purification and analytical workstreams from initial material assessment to delivery of high-quality protein, collaborating with protein engineering and discovery biology teams to troubleshoot challenges and inform candidate design.

This role may be filled at Senior Associate Scientist or Scientist I level based on experience; expected

Qualifications

• BS/MS/PhD in biochemistry or related field with biotechnology/pharma experience.
• Proven purification of antibodies or biologics; high-throughput purification experience.
• Strong analytical skills with SEC-HPLC, CIEX-HPLC, MS, DLS, nanoDSF.
• Excellent communication and teamwork.

Responsibilities

• Execute purification workflows for mono-clonal and bispecific/multi-specific antibodies and other therapeutic proteins using chromatographic techniques (affinity, IEX, HIC, SEC, etc.).
• Characterize biomass quality and impurities; analyze purity distribution, aggregation, charge heterogeneity, and molecule identity; develop methods at analytical/bench scale.
• Optimize purification for small and large-scale productions to support discovery, lead optimization, and preclinical studies.
• Optimize formulation for high concentration and maintain endotoxin control across instruments.
• Troubleshoot production and purification challenges; suggest molecule redesigns when needed.
• Maintain detailed documentation of experiments and protein inventory; present data to teams.

Skills

Analytical skills

SEC-HPLC

CIEX-HPLC

Mass spectrometry

DLS

nanoDSF

Protein purification

Teamwork

Communication

Education

BS in Biochemistry

MS in Biochemistry

PhD in Biochemistry

Tools

Avant CETAC

Benchling

Job description

ImmunEdge is seeking a Senior Research Associate/Scientist to join the protein purification and analytics team in the Biotherapeutics Department. You will own purification and analytical workstreams from initial material assessment to delivery of high-quality protein, collaborating with protein engineering and discovery biology teams to troubleshoot challenges and inform candidate design.

This role may be filled at Senior Associate Scientist or Scientist I level based on experience; expected