Senior Protein Purification Scientist - Antibody Focus

SystImmune, Inc.; Bothell, Northern (WA, KY); Hybrid; USD 70,000 - 90,000; Full time

Benefits offered by this job

Premium health/dental/vision insurance

STD

LTD

401(k) with company match

Job summary

SystImmune, Inc. in Bothell, WA, is seeking a Research Associate or Senior Research Associate to join the Protein Engineering team. You will execute protein purification workflows, support transient mammalian expression, and perform analytical characterization to enable discovery and preclinical development.

This onsite role follows a Thursday–Monday 9:00 AM – 5:00 PM schedule. The successful candidate will grow toward greater scientific independence, maintain detailed records, and collaborate

Qualifications

• Bachelor’s or Master’s degree in Biochemistry, Protein Sciences, Molecular Biology, or related field.
• 2+ years of industry experience for Research Associate II; 5+ years for Senior Research Associate with a bachelor’s, or 3+ years with a Master’s.
• 3+ years hands-on industry experience in protein purification.
• Strong background in protein biochemistry and chromatographic techniques.
• Experience with FPLC ÄKTA purification systems.
• Experience with HPLC/UPLC systems, SEC.
• Familiarity with affinity, ion exchange, and SEC methods.
• Basic understanding of mammalian cell culture techniques.
• Strong organizational and multitasking abilities in a dynamic environment.

Responsibilities

• Execute daily protein purification workflows using FPLC ÄKTA systems (affinity, ion exchange, SEC).
• Develop and support scalable purification processes for antibody and recombinant proteins.
• Operate and maintain FPLC/HPLC/UPLC systems with data integrity.
• Perform analytical characterization of purified proteins, including SEC-based assessments.
• Support transient transfections of CHO cells for mammalian protein expression.
• Assist in cell culture maintenance and harvest for downstream purification.
• Contribute to developability assessments through biochemical/biophysical analyses.
• Maintain detailed experimental records in electronic notebooks.
• Collaborate with researchers to prioritize workflows and meet timelines.
• Drive continuous improvement of purification and analytical workflows.

Skills

Protein purification

FPLC ÄKTA

HPLC/UPLC

Mammalian cell culture

Data management

Organizational skills

Education

Bachelor’s or Master’s in Biochemistry/Protein Sciences/Molecular Biology

Tools

FPLC ÄKTA purification systems

HPLC/UPLC systems

SEC

Job description

SystImmune, Inc. in Bothell, WA, is seeking a Research Associate or Senior Research Associate to join the Protein Engineering team. You will execute protein purification workflows, support transient mammalian expression, and perform analytical characterization to enable discovery and preclinical development.

This onsite role follows a Thursday–Monday 9:00 AM – 5:00 PM schedule. The successful candidate will grow toward greater scientific independence, maintain detailed records, and collaborate