Senior Biologics Engineer & Antibody Platform Lead

Mygwork; Massachusetts; On-site; USD 124,000 - 166,000; Full time

Benefits offered by this job

Medical insurance

Dental insurance

Vision insurance

401(k) with match

Tuition reimbursement

Job summary

Biogen’s BioDesign group seeks an experienced Sr. Scientist to advance biologic therapeutics, designing, engineering, and expressing recombinant proteins and antibodies, including bispecifics and fusions. The role balances hands-on lab work with overseeing external production at CROs within multidisciplinary teams.

The candidate will develop CHO cell lines, support purification and characterization, present findings, and ensure meticulous documentation across electronic notebooks and reports.

Qualifications

• Ph.D. in biochemistry or related field with 2+ years industry experience, or a Master's with 6+ years.
• Strong expertise in molecular biology and protein engineering, including designing antibodies and novel antibody-based formats, including biospecifics and fusion proteins.
• Hands-on experience developing and executing mammalian cell culture, transfection, and expression workflows for recombinant antibody production.
• Competence in protein purification and in vitro analytical characterization techniques (e.g., SEC, Octet).
• Experience characterizing antibody binding, specificity, and cell-surface target engagement using flow cytometry (FACS)-based assays.
• Track record of managing CRO relationships and external protein production.

Responsibilities

• Design, engineer, and express recombinant proteins and antibodies including bispecifics and novel fusions using transient and stable expression platforms.
• Develop stable CHO cell lines for antibody expression as well as mammalian cell lines and reporters to support antibody discovery, screening, and lead optimization.
• Support protein purification and characterization activities, including assessment of antibody binding and cell-surface target engagement using flow cytometry
• Manage all aspects of protein production activities at CRO
• Actively contribute to project strategy and experimental design, and regularly present findings at team meetings
• Document experimental work clearly and completely in electronic lab notebooks and technical reports

Skills

Molecular biology

Protein engineering

Mammalian cell culture

Flow cytometry

Protein purification

Analytical methods

CRO management

Education

Ph.D. in biochemistry or related field

Master's degree with 6+ years industry experience

Job description

Biogen’s BioDesign group seeks an experienced Sr. Scientist to advance biologic therapeutics, designing, engineering, and expressing recombinant proteins and antibodies, including bispecifics and fusions. The role balances hands-on lab work with overseeing external production at CROs within multidisciplinary teams.

The candidate will develop CHO cell lines, support purification and characterization, present findings, and ensure meticulous documentation across electronic notebooks and reports.