Sr. Scientist, Biologics Engineering

Mygwork; Massachusetts; On-site; USD 124,000 - 166,000; Full time

Benefits offered by this job

Medical insurance

Dental insurance

Vision insurance

401(k) with match

Tuition reimbursement

Job summary

Biogen’s BioDesign group seeks an experienced Sr. Scientist to advance biologic therapeutics, designing, engineering, and expressing recombinant proteins and antibodies, including bispecifics and fusions. The role balances hands-on lab work with overseeing external production at CROs within multidisciplinary teams.

The candidate will develop CHO cell lines, support purification and characterization, present findings, and ensure meticulous documentation across electronic notebooks and reports.

Qualifications

• Ph.D. in biochemistry or related field with 2+ years industry experience, or a Master's with 6+ years.
• Strong expertise in molecular biology and protein engineering, including designing antibodies and novel antibody-based formats, including biospecifics and fusion proteins.
• Hands-on experience developing and executing mammalian cell culture, transfection, and expression workflows for recombinant antibody production.
• Competence in protein purification and in vitro analytical characterization techniques (e.g., SEC, Octet).
• Experience characterizing antibody binding, specificity, and cell-surface target engagement using flow cytometry (FACS)-based assays.
• Track record of managing CRO relationships and external protein production.

Responsibilities

• Design, engineer, and express recombinant proteins and antibodies including bispecifics and novel fusions using transient and stable expression platforms.
• Develop stable CHO cell lines for antibody expression as well as mammalian cell lines and reporters to support antibody discovery, screening, and lead optimization.
• Support protein purification and characterization activities, including assessment of antibody binding and cell-surface target engagement using flow cytometry
• Manage all aspects of protein production activities at CRO
• Actively contribute to project strategy and experimental design, and regularly present findings at team meetings
• Document experimental work clearly and completely in electronic lab notebooks and technical reports

Skills

Molecular biology

Protein engineering

Mammalian cell culture

Flow cytometry

Protein purification

Analytical methods

CRO management

Education

Ph.D. in biochemistry or related field

Master's degree with 6+ years industry experience

Job description

About This Role

The BioDesign group at Biogen is seeking an experienced and highly motivated scientist to contribute to the discovery and development of innovative biologic therapeutics. The Sr. Scientist will contribute to multiple research programs through the design, engineering, and expression of recombinant proteins, including antibodies and other biologic modalities. Leveraging expertise in molecular biology, protein engineering, and mammalian cell engineering, this individual will balance hands-on laboratory research with oversight of external protein production efforts at CROs while collaborating across multidisciplinary project teams to advance the therapeutic pipeline

What You'll Do

• Design, engineer, and express recombinant proteins and antibodies including bispecifics and novel fusions using transient and stable expression platforms.
• Develop stable CHO cell lines for antibody expression as well as mammalian cell lines and reporters to support antibody discovery, screening, and lead optimization.
• Support protein purification and characterization activities, including assessment of antibody binding and cell-surface target engagement using flow cytometry
• Manage all aspects of protein production activities at CRO
• Actively contribute to project strategy and experimental design, and regularly present findings at team meetings
• Document experimental work clearly and completely in electronic lab notebooks and technical reports

Who You Are

You are an independent and innovative scientist with strong expertise in molecular biology, antibody engineering, and mammalian cell culture. You enjoy working in a collaborative, team-oriented environment and are motivated by solving complex scientific challenges. You have a track record of scientific achievement, strong communication skills, and the ability to balance multiple priorities while contributing to shared team goals

Required Skills

• Ph.D. in biochemistry or a related field with 2+ years experience industry experience, or a Master's degree with 6+ years relevant industry experience.
• Strong expertise in molecular biology and protein engineering, with demonstrated experience designing antibodies and novel antibody-based formats, including biospecifics and fusion proteins
• Hands-on experience developing and executing mammalian cell culture, transfection, and expression workflows for recombinant antibody production
• Competence in protein purification and in vitro analytical characterization techniques (e.g., SEC, Octet,)
• Experience characterizing antibody binding, specificity, and cell-surface target engagement using flow cytometry (FACS)-based assays.
• Track record of managing CRO relationships and external protein production
• Strong organizational skills and attention to detail
• Excellent communication and data presentation skills

Preferred Skills

• Direct experience with antibody-oligonucleotide conjugates and other complex modalities.
• Expertise in advanced cell engineering technologies including lentiviral transduction and gene editing technologies.
• Familiarity with mass spectrometry-based characterization of antibody therapeutics and engineered biologics

Job Level: Management

Additional Information

The base compensation range for this role is: $124,000.00-$166,000.00

Base salary offered is determined through an analytical approach utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity.

Regular employees are eligible to receive both short term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward recent achievements and recognize your future potential based on individual, business unit and company performance.

In addition to compensation, Biogen offers a full and highly competitive range of benefits designed to support our employees' and their families physical, financial, emotional, and social well-being; including, but not limited to:

• Medical, Dental, Vision, & Life insurances
• Fitness & Wellness programs including a fitness reimbursement
• Short- and Long-Term Disability insurance
• A minimum of 15 days of paid vacation and an additional end-of-year shutdown time off (Dec 26-Dec 31)
• Up to 12 company paid holidays + 3 paid days off for Personal Significance
• 80 hours of sick time per calendar year
• Paid Maternity and Parental Leave benefit
• 401(k) program participation with company matched contributions
• Employee stock purchase plan
• Tuition reimbursement of up to $10,000 per calendar year
• Employee Resource Groups participation

Why Biogen?

We are a global team with a commitment to excellence, and a pioneering spirit. As a mid-sized biotechnology company, we provide the stability and resources of a well-established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills. Above all, we work together to deliver life-changing medicines, with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives.

At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired. Read on to learn more about Biogen.

All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States.