Senior Antibody Bioconjugation Scientist (Automation Ready)

Initial Therapeutics, Inc.

Brisbane (CA)

On-site

USD 155,000 - 180,000

Full time

14 days+

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Job summary

Nurix Therapeutics, Inc. seeks a hands-on antibody conjugation scientist to build a new capability from the ground up, partnering across medicinal chemistry, analytical chemistry, computation, protein biochemistry and automation to move candidates toward study-ready material.

You will develop and optimize bioconjugation methods, design automation-friendly protocols, and scale conjugations from mg to multi-mg to support pharmacology and PK/PD studies in a fast-paced, collaborative discovery

Qualifications

PhD in chemistry, biochemistry, chemical biology, or related field; MS or BS with substantial hands-on industry bioconjugation experience will also be considered.
Direct, hands-on experience with antibody/protein bioconjugation chemistry: NHS ester and maleimide coupling, click chemistry (CuAAC/SPAAC/IEDDA), engineered-cysteine or glycan/enzymatic site-specific conjugation, or unnatural-amino-acid approaches.
Experience purifying and characterizing conjugates: FPLC/AKTA, TFF, SEC, IEX, RP-HPLC/UPLC, HIC, and LC-MS-based DAR/identity analysis.
Experience preparing protocols for automated or semi-automated execution (e.g., liquid handlers such as Hamilton or Tecan) is a strong plus, though the successful candidate may also learn this in partnership with our automation team.
Strong record of practical problem-solving in the lab, with the judgment to know when a result is study-ready versus needs more optimization.

Responsibilities

Develop and optimize antibody bioconjugation methods for attaching degrader payloads and linkers to antibodies.
Design conjugation chemistry with an eye toward automation: define protocols, reagent ratios, and process parameters in a form that can be transferred to and run reliably on liquid-handling platforms.
Execute one-off and scale-up conjugation runs (mg to multi-mg) to produce material for pharmacology, PK/PD, and other advanced studies on program timelines.
Purify conjugates via FPLC/AKTA, TFF, and column chromatography; troubleshoot yield, homogeneity, and stability issues as they arise.
Write clear SOPs and technical reports; train and support automation-team colleagues in executing conjugation workflows independently.
Collaborate cross-functionally with medicinal chemists (linker/payload design), computational chemists (site selection, modeling), and external CROs/CDMOs as needed.
Stay current on emerging bioconjugation and DAC/ADC methodology and bring forward new techniques relevant to Nurix's pipeline.