Founding Antibody Conjugation Scientist with Equity

Nurix, Inc.; California (MO); On-site; USD 155,000 - 180,000; Full time

Job summary

Nurix Therapeutics, Inc. is seeking a hands-on antibody conjugation scientist to build a new bioconjugation capability from the ground up within our collaborative discovery organization.

You will partner with medicinal, analytical, computational chemistry, protein biochemistry and automation teams to move antibody conjugates from bench to study-ready material, with scale-up and automation in mind. Salary range is competitive with equity and bonus; this role offers the opportunity to establish

Qualifications

• PhD in chemistry, biochemistry, chemical biology, or a related field preferred; MS or BS with substantial (8+ for BS/MS) hands-on industry bioconjugation experience will also be considered.
• Direct, hands-on experience with antibody/protein bioconjugation chemistry: NHS ester and maleimide coupling, click chemistry (CuAAC/SPAAC/IEDDA), engineered-cysteine or glycan/enzymatic site-specific conjugation, or unnatural-amino-acid approaches.
• Experience purifying and characterizing conjugates: FPLC/AKTA, TFF, SEC, IEX, RP-HPLC/UPLC, HIC, and LC-MS-based DAR/identity analysis.
• Experience preparing protocols for automated or semi-automated execution (e.g., liquid handlers such as Hamilton or Tecan) is a strong plus, though the successful candidate may also learn this in partnership with our automation team.
• Strong record of practical problem-solving in the lab, with the judgment to know when a result is study-ready versus needs more optimization

Responsibilities

• Develop and optimize antibody bioconjugation methods for attaching degrader payloads and linkers to antibodies.
• Design conjugation chemistry with an eye toward automation: define protocols, reagent ratios, and process parameters in a form that can be transferred to and run reliably on liquid-handling platforms.
• Execute one-off and scale-up conjugation runs (mg to multi-mg) to produce material for pharmacology, PK/PD, and other advanced studies on program timelines.
• Purify conjugates via FPLC/AKTA, TFF, and column chromatography; troubleshoot yield, homogeneity, and stability issues as they arise.
• Write clear SOPs and technical reports; train and support automation-team colleagues in executing conjugation workflows independently.
• Collaborate cross-functionally with medicinal chemists (linker/payload design), computational chemists (site selection, modeling), and external CROs/CDMOs as needed.
• Stay current on emerging bioconjugation and DAC/ADC methodology and bring forward new techniques relevant to Nurix's pipeline.

Skills

Team collaboration

Results-oriented

Autonomy

Communication

Education

PhD in chemistry/biochemistry/chemical biology or related field

MS/BS with substantial hands-on bioconjugation experience

Tools

FPLC/AKTA

TFF

SEC

IEX

RP-HPLC/UPLC

HIC

LC-MS (DAR/identity)

Hamilton/Tecan liquid handlers

Job description

Nurix Therapeutics, Inc. is seeking a hands-on antibody conjugation scientist to build a new bioconjugation capability from the ground up within our collaborative discovery organization.

You will partner with medicinal, analytical, computational chemistry, protein biochemistry and automation teams to move antibody conjugates from bench to study-ready material, with scale-up and automation in mind. Salary range is competitive with equity and bonus; this role offers the opportunity to establish