Senior Analytical Scientist: LC-MS & Biomolecule Analysis

ManpowerGroup; St. Louis (MO); On-site; USD 67,000 - 96,000; Full time

Benefits offered by this job

Medical benefits

Dental benefits

Vision benefits

401(k) plan

Job summary

ManpowerGroup is seeking a Sr. Analytical Scientist in St. Louis, MO for a client in Life Science and Biotechnology. Develop and optimize LC-MS assays to quantify proteins in complex samples and characterize monoclonal antibodies, multispecific antibodies, and ADCs.

The role requires independent work, strong analytical problem-solving, and excellent scientific communication, with engagement across R&D, manufacturing, and cross-functional teams.

Qualifications

• BS in Chemistry or related field; PhD preferred
• Hands-on experience with high-resolution and/or triple quadrupole LC-MS instrumentation
• Experience with protein characterization and sample preparation techniques such as digestion, enrichment, depletion, and labeling
• Knowledge of large biomolecule workflows including peptide mapping, PTM characterization, glycosylation profiling, or intact mass analysis
• Ability to work independently in a laboratory environment and collaborate effectively within multidisciplinary teams

Responsibilities

• Develop and optimize LC-MS assays for quantitative analysis of proteins in complex biological samples
• Perform advanced characterization of biomolecules including monoclonal antibodies, multispecific antibodies, and antibody-drug conjugates (ADCs)
• Provide analytical support to R&D, manufacturing, and cross-functional project teams
• Operate and troubleshoot advanced mass spectrometry instrumentation and analytical workflows
• Analyze, interpret, and communicate scientific data to support research and product development initiatives

Skills

Analytical problem-solving

Independent work

Scientific communication

Education

Bachelor's degree in Chemistry or related field

PhD in Analytical Chemistry or related field (preferred)

Tools

LC-MS instrumentation (HRMS / triple quadrupole)

Job description

ManpowerGroup is seeking a Sr. Analytical Scientist in St. Louis, MO for a client in Life Science and Biotechnology. Develop and optimize LC-MS assays to quantify proteins in complex samples and characterize monoclonal antibodies, multispecific antibodies, and ADCs.

The role requires independent work, strong analytical problem-solving, and excellent scientific communication, with engagement across R&D, manufacturing, and cross-functional teams.