Sr. Analytical Scientist

Randstad USA; St. Louis (MO); On-site; USD 55,000 - 110,000; Part time

Job summary

MilliporeSigma, part of Merck KGaA, Darmstadt, Germany, is seeking a Senior Scientist to join the Analytical R&D Department in St. Louis. You will lead LC-MS assay development for protein quantitation in complex mixtures and characterize large biomolecules such as antibodies and ADCs.

The role requires a BS in Chemistry or related field, hands-on LC-MS expertise, and the ability to work independently and in a team. Preference for PhD and broader MS/MS workflow experience.

Qualifications

• BS in Chemistry or related field.
• Hands-on proficiency with advanced instrumentation, including high resolution and triple quadrupole LC-MS.
• Expertise in sample preparation for large biomolecules LC-MS (digestion, enrichment, depletion, labelling).
• Ability to work independently and in a team.

Responsibilities

• Lead development of LC-MS assays for quantitation of proteins in complex mixtures.
• Perform advanced characterization of large biomolecules including monoclonal antibodies, multispecifics, and antibody drug conjugates.

Skills

Team collaboration

Independent work

Effective communication

Education

BS in Chemistry or related field

Tools

LC-MS platforms

MALDI-MS

UNIFI

BioPharma Finder

Mascot

Scaffold

Thermo, Sciex, Waters, Agilent

Job description

***6-month contract opportunity with possiblity of conversion***

A career with MilliporeSigma is an ongoing journey of discovery: our 56,000 people are shaping how the world lives, works and plays through next generation advancements in healthcare, life science and performance materials. For more than 350 years and across the world we have passionately pursued our curiosity to find novel and vibrant ways of enhancing the lives of others. MilliporeSigma is a business of Merck KGaA, Darmstadt, Germany.

Your Role:

The Senior Scientist will join the Analytical R&D Department at MilliporeSigma at our Life Sciences R&D facility in St. Louis. In this role, you will be part of an active, multidisciplinary group of scientists dedicated to providing high level analytical support to product development scientists in R&D, manufacturing groups, and special project teams. You will be expected to lead development of LC-MS assays for the quantitation of proteins in complex mixtures. Additionally, you will perform advanced characterization of large biomolecules including monoclonal antibodies, multispecifics, and antibody drug conjugates.

Who you are:

Minimum Qualifications:

• BS in Chemistry or related field
• Demonstrated hands-on proficiency with advanced instrumentation, such as with high resolution and triple quadrupole LC-MS platforms
• Expertise with a variety of enzymatic and chemical methods of sample preparation for large biomolecule LC-MS, such as digestion, enrichment, depletion, and labelling
• The ability to work and communicate effectively both independently and in a team-oriented environment

Preferred Qualifications:

• PhD in Analytical Chemistry or related field
• Expertise in absolute quantitation of proteins and antibodies by Multiple Reaction Monitoring (MRM) and/or Parallel Reaction Monitoring (PRM) mass spectrometry
• Expertise in bottom up, middle up/down, and top down protein LC-MS workflows
• Experience with specific workflows such as non-reduced and reduced intact mass analysis, peptide mapping, disulfide mapping, Post-Translational Modifications (PTM) characterization, glycosylation profiling, and free thiol analysis
• Expertise with bioinformatics related to the quantitation and characterization of large biomolecules such as UNIFI, BioPharma Finder, Mascot, and Scaffold
• Ideal candidate would have proficiency in a variety of instrument platforms such as Thermo, Sciex, Waters, and Agilent mass spectrometers
• In addition to ESI-MS techniques the ideal candidate would also have hands-on experience with MALDI-MS